Cyclin-dependent kinase 1 | RAC-alpha serine/threonine-protein kinase (Rattus) | Serine/threonine-protein kinase Chk1 |
Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
Cyclin-dependent kinase 1 - CDK1 -  Homo sapiens | ||||||||
LIG_14-3-3_3 | MPIP2_HUMAN | 320 | 325 | Binary | Physicochemical compatibility | Phosphorylation of S321 in the 14-3-3-binding motif of M-phase inducer phosphatase 2 (CDC25B) by Cyclin-dependent kinase 1 (CDK1) during mitosis abolishes binding of the motif, phosphorylated at S323, to 14-3-3 protein beta/alpha (YWHAB), thereby maintaining active Cdc25B. | Curated | |
RAC-alpha serine/threonine-protein kinase - AKT1 -  Rattus norvegicus | ||||||||
LIG_14-3-3_1 | BAD_RAT | 134 | 139 | Binary | Physicochemical compatibility | Phosphorylation of S137 by RAC-alpha serine/threonine-protein kinase (Akt1) in the 14-3-3-binding motif of Bcl2 antagonist of cell death (Bad) induces binding to the 14-3-3 protein beta/alpha (YWHAB) protein. This interaction inhibits the pro-apoptotic activity of Bcl2 antagonist of cell death (Bad). | Curated | |
Serine/threonine-protein kinase Chk1 - CHEK1 -  Homo sapiens | ||||||||
LIG_14-3-3_3 | MPIP3_HUMAN | 213 | 218 | Binary | Physicochemical compatibility | Phosphorylation of S216 in a 14-3-3-binding motif of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase Chk1 (CHEK1) induces binding to 14-3-3 protein beta/alpha (YWHAB), which negatively regulates M-phase inducer phosphatase 3 (CDC25C). | Curated |