switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:Q9Y490 (3 hits) x

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Curated inferred

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Evidence

Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens
LIG_PTB_Apo_2	ITB3_HUMAN	767	774	Specificity	Altered binding specificity	Phosphorylation of Y773 in Integrin beta-3 (ITGB3) switches the specificity of ITGB3 from Talin-1 (TLN1) to Docking protein 1 (DOK1), with a 2-fold decrease of the affinity for TLN1 and close to a 400-fold increase of the affinity for DOK1. This switch results in negative regulation of integrin activation.	details	Inferred
LIG_PTB_Apo_2	ITB3_HUMAN	767	774	Specificity	Altered binding specificity	Phosphorylation of Y773 in Integrin beta-3 (ITGB3) switches the specificity of ITGB3 from Talin-1 (TLN1) to Docking protein 1 (DOK1), with a 2-fold decrease of the affinity for TLN1 and close to a 400-fold increase of the affinity for DOK1. This switch results in negative regulation of integrin activation.	details	Inferred
LIG_PTB_Apo_2	ITB3_HUMAN	767	774	Specificity	Altered binding specificity	Phosphorylation of Y773 in Integrin beta-3 (ITGB3) switches the specificity of ITGB3 from Talin-1 (TLN1) to Docking protein 1 (DOK1), with a 2-fold decrease of the affinity for TLN1 and close to a 400-fold increase of the affinity for DOK1. This switch results in negative regulation of integrin activation.	details	Inferred