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| I-kappa-B kinase subfamily () | Negative regulator of sexual conjugation and meiosis (Schizosaccharomyces) | PKC subfamily () |
| Protein kinase C alpha type | RAC-alpha serine/threonine-protein kinase |
| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
I-kappa-B kinase subfamily | ||||||||
| LIG_14-3-3_2 | TF65_HUMAN | 41 | 47 | Binary | Physicochemical compatibility | Phosphorylation of S45 by in the 14-3-3-binding motif of Transcription factor p65 (RELA) induces binding to the 14-3-3 protein eta (YWHAH) protein. | Curated | |
PKC subfamily | ||||||||
| LIG_14-3-3_2 | PDE3A_HUMAN | 424 | 430 | Binary | Physicochemical compatibility | Phosphorylation of S428 by in the 14-3-3-binding motif of cGMP-inhibited 3',5'-cyclic phosphodiesterase A (PDE3A) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein. | Curated | |
Negative regulator of sexual conjugation and meiosis - RAN1 - Schizosaccharomyces pombe (strain 972 / ATCC 24843) | ||||||||
| LIG_14-3-3_2 | MEI2_SCHPO | 523 | 529 | Avidity‑sensing | Phosphorylation of two 14-3-3-binding motifs in Meiosis protein mei2 (mei2) by Negative regulator of sexual conjugation and meiosis (ran1) induces high-avidity binding to dimeric DNA damage checkpoint protein rad24 (rad24), with pT527 being the high-affinity interaction site. | Curated | ||
Protein kinase C alpha type - PRKCA - Homo sapiens | ||||||||
| LIG_14-3-3_2 | PDE3A_HUMAN | 424 | 430 | Binary | Physicochemical compatibility | Phosphorylation of S428 by in the 14-3-3-binding motif of cGMP-inhibited 3',5'-cyclic phosphodiesterase A (PDE3A) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein. | Inferred | |
RAC-alpha serine/threonine-protein kinase - AKT1 - Homo sapiens | ||||||||
| LIG_14-3-3_2 | FOXO4_HUMAN | 193 | 199 | Binary | Physicochemical compatibility | Phosphorylation of S197 by in the 14-3-3-binding motif of Forkhead box protein O4 (FOXO4) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein. | Curated | |
| LIG_14-3-3_2 | FOXO4_HUMAN | 193 | 199 | Avidity‑sensing | Phosphorylation of two 14-3-3-binding motifs in Foxo4 by PKB induces binding of 14-3-3 dimer. In the nucleus, this blocks binding to DNA, while in the cytoplasm it blocks reimport of Foxo4 into the nucleus by blocking its Nuclear Localisation Signal (NLS). Since binding of 14-3-3 to a single motif occurs with an affinity similar to the affinity of Foxo4 for DNA, multivalent binding of 14-3-3 dimer is required for efficient inhibition of DNA binding. | Curated | ||