switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:LIG_PDZ_Class_1 (6 hits) x

x Coloured by: Modifier evidence source
Curated inferred

x Index

Beta-adrenergic receptor kinase 1	Beta-adrenergic receptor kinase 1 (Bos)	G protein-coupled receptor kinase 5
cAMP subfamily ()	cAMP-dependent protein kinase catalytic subunit alpha (Mus)

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

cAMP subfamily
LIG_PDZ_Class_1	CCG2_MOUSE	318	323	Binary	Physicochemical compatibility	Phosphorylation of T321 in the PDZ-binding motif of Voltage-dependent calcium channel gamma-2 subunit (Cacng2) by cAMP subfamily prevents binding to the PDZ domain of Disks large homolog 4 (Dlg4), an interaction involved in regulating synaptic targeting of AMPA-selective glutamate receptors.	details	Curated
LIG_PDZ_Class_1	IRK4_HUMAN	440	445	Binary	Physicochemical compatibility	Phosphorylation of S443 in the PDZ-binding motif of Inward rectifier potassium channel 4 (KCNJ4) by inhibits its interaction with the Disks large homolog 4 (DLG4) protein.	details	Curated
Beta-adrenergic receptor kinase 1 - ADRBK1 - Bos taurus
LIG_PDZ_Class_1	PGFRB_HUMAN	1101	1106	Binary	Physicochemical compatibility	Phosphorylation of S1104 in the PDZ-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) by Beta-adrenergic receptor kinase 1 (ADRBK1) inhibits binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1). Binding of Platelet-derived growth factor receptor beta (PDGFRB) to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) potentiates dimerisation and signalling of the receptor, while phosphorylation at S1104 desensitises the receptor.	details	Inferred
Beta-adrenergic receptor kinase 1 - ADRBK1 - Homo sapiens
LIG_PDZ_Class_1	PGFRB_HUMAN	1101	1106	Binary	Physicochemical compatibility	Phosphorylation of S1104 in the PDZ-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) by Beta-adrenergic receptor kinase 1 (ADRBK1) inhibits binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1). Binding of Platelet-derived growth factor receptor beta (PDGFRB) to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) potentiates dimerisation and signalling of the receptor, while phosphorylation at S1104 desensitises the receptor.	details	Curated
G protein-coupled receptor kinase 5 - GRK5 - Homo sapiens
LIG_PDZ_Class_1	ADRB2_HUMAN	408	413	Binary	Physicochemical compatibility	Phosphorylation of S411 in the PDZ-binding motif of Beta-2 adrenergic receptor (ADRB2) by inhibits its interaction with the Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) protein.	details	Curated
cAMP-dependent protein kinase catalytic subunit alpha - PRKACA - Mus musculus
LIG_PDZ_Class_1	CCG2_MOUSE	318	323	Binary	Physicochemical compatibility	Phosphorylation of T321 in the PDZ-binding motif of Voltage-dependent calcium channel gamma-2 subunit (Cacng2) by cAMP subfamily prevents binding to the PDZ domain of Disks large homolog 4 (Dlg4), an interaction involved in regulating synaptic targeting of AMPA-selective glutamate receptors.	details	Inferred