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| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
3-phosphoinositide-dependent protein kinase 1 - PDPK1 - Homo sapiens | ||||||||
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Binary | Physicochemical compatibility | Phosphorylation of T779 in the PTB-binding motif of Integrin beta-3 (ITGB3) inhibits its interaction with SHC-transforming protein 1 (SHC1). | Inferred | |
Epidermal growth factor receptor - EGFR - Homo sapiens | ||||||||
| LIG_PTB_Phospho_1 | EGFR_HUMAN | 1104 | 1110 | Binary | Physicochemical compatibility | Phosphorylation of Y1110 in the PTB-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Docking protein 1 (DOK1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | EGFR_HUMAN | 1104 | 1110 | Binary | Physicochemical compatibility | Phosphorylation of Y1110 in the PTB-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Docking protein 1 (DOK1) protein. | Inferred | |
High affinity nerve growth factor receptor - NTRK1 - Homo sapiens | ||||||||
| LIG_PTB_Phospho_1 | NTRK1_HUMAN | 490 | 496 | Binary | Physicochemical compatibility | Phosphorylation of Y496 in the PTB-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | NTRK1_HUMAN | 490 | 496 | Binary | Physicochemical compatibility | Phosphorylation of Y496 in the PTB-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | NTRK1_HUMAN | 490 | 496 | Binary | Physicochemical compatibility | Phosphorylation of Y496 in the PTB-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein. | Inferred | |
Insulin receptor - INSR - Homo sapiens | ||||||||
| LIG_PTB_Phospho_1 | INSR_HUMAN | 993 | 999 | Binary | Physicochemical compatibility | Phosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | INSR_HUMAN | 993 | 999 | Binary | Physicochemical compatibility | Phosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | INSR_HUMAN | 993 | 999 | Binary | Physicochemical compatibility | Phosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | INSR_HUMAN | 993 | 999 | Binary | Physicochemical compatibility | Phosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein. | Inferred | |
Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens | ||||||||
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 767 | 773 | Binary | Physicochemical compatibility | Phosphorylation of Y773 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the Docking protein 1 (DOK1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 767 | 773 | Binary | Physicochemical compatibility | Phosphorylation of Y773 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the Docking protein 1 (DOK1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 767 | 773 | Binary | Physicochemical compatibility | Phosphorylation of Y773 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the Docking protein 1 (DOK1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Binary | Physicochemical compatibility | Phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the SHC-transforming protein 1 (SHC1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Binary | Physicochemical compatibility | Phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the SHC-transforming protein 1 (SHC1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | LRP1_HUMAN | 4501 | 4507 | Binary | Physicochemical compatibility | Phosphorylation of Y4507 in the PTB-binding motif of Prolow-density lipoprotein receptor-related protein 1 (LRP1) induces binding to the SHC-transforming protein 1 (SHC1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | LRP1_HUMAN | 4501 | 4507 | Binary | Physicochemical compatibility | Phosphorylation of Y4507 in the PTB-binding motif of Prolow-density lipoprotein receptor-related protein 1 (LRP1) induces binding to the SHC-transforming protein 1 (SHC1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Cumulative | Rheostatic | While phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Cumulative | Rheostatic | While phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Cumulative | Rheostatic | While phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Cumulative | Rheostatic | While phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Cumulative | Rheostatic | While phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 767 | 773 | Specificity | Altered binding specificity | Phosphorylation of Y773 in Integrin beta-3 (ITGB3) switches the specificity of ITGB3 from Talin-1 (TLN1) to Docking protein 1 (DOK1), with a 2-fold decrease of the affinity for TLN1 and close to a 400-fold increase of the affinity for DOK1. This switch results in negative regulation of integrin activation. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 767 | 773 | Specificity | Altered binding specificity | Phosphorylation of Y773 in Integrin beta-3 (ITGB3) switches the specificity of ITGB3 from Talin-1 (TLN1) to Docking protein 1 (DOK1), with a 2-fold decrease of the affinity for TLN1 and close to a 400-fold increase of the affinity for DOK1. This switch results in negative regulation of integrin activation. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 767 | 773 | Specificity | Altered binding specificity | Phosphorylation of Y773 in Integrin beta-3 (ITGB3) switches the specificity of ITGB3 from Talin-1 (TLN1) to Docking protein 1 (DOK1), with a 2-fold decrease of the affinity for TLN1 and close to a 400-fold increase of the affinity for DOK1. This switch results in negative regulation of integrin activation. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Specificity | Altered binding specificity | Phosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1). | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Specificity | Altered binding specificity | Phosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1). | Inferred | |
Proto-oncogene tyrosine-protein kinase receptor Ret - RET - Mus musculus | ||||||||
| LIG_PTB_Phospho_1 | RET_MOUSE | 1057 | 1063 | Binary | Physicochemical compatibility | Phosphorylation of Y1063 in the PTB-binding motif of Proto-oncogene tyrosine-protein kinase receptor Ret (Ret) induces binding to the Docking protein 1 (Dok1) protein. | Inferred | |
Tyrosine-protein kinase SYK - SYK - Homo sapiens | ||||||||
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Binary | Physicochemical compatibility | Phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the SHC-transforming protein 1 (SHC1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Cumulative | Rheostatic | While phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Specificity | Altered binding specificity | Phosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1). | Inferred | |