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ELM:LIG_SH2_IC (20 hits)
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Index
Epidermal growth factor receptor
Hepatocyte growth factor receptor
Insulin-like growth factor 1 receptor
Macrophage-stimulating protein receptor
Neuronal proto-oncogene tyrosine-protein kinase Src
(Mus)
Proto-oncogene tyrosine-protein kinase Src
Receptor tyrosine-protein kinase erbB-2
Tyrosine-protein kinase ABL1
Tyrosine-protein kinase SYK
Tyrosine-protein kinase ZAP-70
Vascular endothelial growth factor receptor 3
Motif
Protein
Start
End
Switch Type
Switch Subtype
Switch description
Information
Evidence
Epidermal growth factor receptor -
EGFR
-  
Homo sapiens
LIG_SH2_IC
EGFR_HUMAN
1092
1100
Binary
Physicochemical compatibility
Phosphorylation of Y1092 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred
LIG_SH2_IC
EGFR_HUMAN
1092
1100
Binary
Physicochemical compatibility
Phosphorylation of Y1092 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred
Hepatocyte growth factor receptor -
MET
-  
Homo sapiens
LIG_SH2_IC
MET_HUMAN
1351
1360
Binary
Physicochemical compatibility
Phosphorylation of Y1356 in the SH2-binding motif of
Hepatocyte growth factor receptor (MET)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred
LIG_SH2_IC
MET_HUMAN
1351
1360
Binary
Physicochemical compatibility
Phosphorylation of Y1356 in the SH2-binding motif of
Hepatocyte growth factor receptor (MET)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred
LIG_SH2_IC
MET_HUMAN
1351
1360
Binary
Physicochemical compatibility
Phosphorylation of Y1356 in the SH2-binding motif of
Hepatocyte growth factor receptor (MET)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred
LIG_SH2_IC
MET_HUMAN
1351
1360
Binary
Physicochemical compatibility
Phosphorylation of Y1356 in the SH2-binding motif of
Hepatocyte growth factor receptor (MET)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred
LIG_SH2_IC
SHC1_HUMAN
423
435
Binary
Physicochemical compatibility
Phosphorylation of Y427 in the SH2-binding motif of
SHC-transforming protein 1 (SHC1)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred
Insulin-like growth factor 1 receptor -
IGF1R
-  
Homo sapiens
LIG_SH2_IC
PDPK1_HUMAN
376
379
Binary
Physicochemical compatibility
Phosphorylation of Y376 in the SH2-binding motif of
3-phosphoinositide-dependent protein kinase 1 (PDPK1)
induces binding to the
Tensin-1 (TNS1)
protein.
details
Inferred
Macrophage-stimulating protein receptor -
MST1R
-  
Homo sapiens
LIG_SH2_IC
MET_HUMAN
1351
1360
Binary
Physicochemical compatibility
Phosphorylation of Y1356 in the SH2-binding motif of
Hepatocyte growth factor receptor (MET)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred
Neuronal proto-oncogene tyrosine-protein kinase Src -
SRC
-  
Mus musculus
LIG_SH2_IC
EGFR_HUMAN
1092
1100
Binary
Physicochemical compatibility
Phosphorylation of Y1092 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred
Proto-oncogene tyrosine-protein kinase Src -
SRC
-  
Homo sapiens
LIG_SH2_IC
PDPK1_HUMAN
376
379
Binary
Physicochemical compatibility
Phosphorylation of Y376 in the SH2-binding motif of
3-phosphoinositide-dependent protein kinase 1 (PDPK1)
induces binding to the
Tensin-1 (TNS1)
protein.
details
Inferred
LIG_SH2_IC
PDPK1_HUMAN
376
379
Binary
Physicochemical compatibility
Phosphorylation of Y376 in the SH2-binding motif of
3-phosphoinositide-dependent protein kinase 1 (PDPK1)
induces binding to the
Tensin-1 (TNS1)
protein.
details
Inferred
LIG_SH2_IC
SHC1_HUMAN
423
435
Binary
Physicochemical compatibility
Phosphorylation of Y427 in the SH2-binding motif of
SHC-transforming protein 1 (SHC1)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred
Receptor tyrosine-protein kinase erbB-2 -
ERBB2
-  
Homo sapiens
LIG_SH2_IC
ERBB2_HUMAN
1135
1144
Binary
Physicochemical compatibility
Phosphorylation of Y1139 in the SH2-binding motif of
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
induces binding to the
Growth factor receptor-bound protein 7 (GRB7)
protein.
details
Inferred
LIG_SH2_IC
ERBB2_HUMAN
1135
1144
Binary
Physicochemical compatibility
Phosphorylation of Y1139 in the SH2-binding motif of
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
induces binding to the
Growth factor receptor-bound protein 7 (GRB7)
protein.
details
Inferred
Tyrosine-protein kinase ABL1 -
ABL1
-  
Homo sapiens
LIG_SH2_IC
EGFR_HUMAN
1092
1100
Binary
Physicochemical compatibility
Phosphorylation of Y1092 in the SH2-binding motif of
Epidermal growth factor receptor (EGFR)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred
LIG_SH2_IC
MET_HUMAN
1351
1360
Binary
Physicochemical compatibility
Phosphorylation of Y1356 in the SH2-binding motif of
Hepatocyte growth factor receptor (MET)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred
Tyrosine-protein kinase SYK -
SYK
-  
Homo sapiens
LIG_SH2_IC
SHC1_HUMAN
423
435
Binary
Physicochemical compatibility
Phosphorylation of Y427 in the SH2-binding motif of
SHC-transforming protein 1 (SHC1)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred
Tyrosine-protein kinase ZAP-70 -
ZAP70
-  
Homo sapiens
LIG_SH2_IC
SHC1_HUMAN
423
435
Binary
Physicochemical compatibility
Phosphorylation of Y427 in the SH2-binding motif of
SHC-transforming protein 1 (SHC1)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred
Vascular endothelial growth factor receptor 3 -
FLT4
-  
Homo sapiens
LIG_SH2_IC
SHC1_HUMAN
423
435
Binary
Physicochemical compatibility
Phosphorylation of Y427 in the SH2-binding motif of
SHC-transforming protein 1 (SHC1)
induces binding to the
Growth factor receptor-bound protein 2 (GRB2)
protein.
details
Inferred