switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:LIG_SH3_2 (12 hits) x

x Coloured by: Modifier evidence source
Curated inferred

x Index

Cyclin-dependent kinase 5	GSK-3 subfamily ()	Mitogen-activated protein kinase 1
Mitogen-activated protein kinase 10	Mitogen-activated protein kinase 3 (Rattus)	Mitogen-activated protein kinase 8
Mitogen-activated protein kinase 9	NP_446294 (?)	RAC subfamily ()
Serine/threonine-protein kinase mTOR	cGMP-dependent protein kinase 1

Motif

Protein

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End

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Information

Evidence

GSK-3 subfamily
LIG_SH3_2	MYC_HUMAN	60	65	Binary	Physicochemical compatibility	Phosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).	details	Curated
RAC subfamily
LIG_SH3_2	PAK1_HUMAN	13	18	Binary	Physicochemical compatibility	Phosphorylation of S21 adjacent to the SH3-binding motif of Serine/threonine-protein kinase PAK 1 (PAK1) by RAC subfamily inhibits binding to Cytoplasmic protein NCK1 (NCK1), which regulates its localization to focal contacts.	details	Curated
Cyclin-dependent kinase 5 - CDK5 - Homo sapiens
LIG_SH3_2	MYC_HUMAN	60	65	Binary	Physicochemical compatibility	Phosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).	details	Inferred
Mitogen-activated protein kinase 1 - MAPK1 - Homo sapiens
LIG_SH3_2	MYC_HUMAN	60	65	Binary	Physicochemical compatibility	Phosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).	details	Inferred
LIG_SH3_2	MYC_HUMAN	60	65	Binary	Physicochemical compatibility	Phosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).	details	Inferred
Mitogen-activated protein kinase 10 - MAPK10 - Homo sapiens
LIG_SH3_2	MYC_HUMAN	60	65	Binary	Physicochemical compatibility	Phosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).	details	Inferred
Mitogen-activated protein kinase 3 - MAPK3 - Rattus norvegicus
LIG_SH3_2	MYC_HUMAN	60	65	Binary	Physicochemical compatibility	Phosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).	details	Inferred
Mitogen-activated protein kinase 8 - MAPK8 - Homo sapiens
LIG_SH3_2	MYC_HUMAN	60	65	Binary	Physicochemical compatibility	Phosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).	details	Inferred
Mitogen-activated protein kinase 9 - MAPK9 - Homo sapiens
LIG_SH3_2	MYC_HUMAN	60	65	Binary	Physicochemical compatibility	Phosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).	details	Inferred
NP_446294 - ? - ?
LIG_SH3_2	MYC_HUMAN	60	65	Binary	Physicochemical compatibility	Phosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).	details	Inferred
Serine/threonine-protein kinase mTOR - MTOR - Homo sapiens
LIG_SH3_2	MYC_HUMAN	60	65	Binary	Physicochemical compatibility	Phosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).	details	Inferred
cGMP-dependent protein kinase 1 - PRKG1 - Homo sapiens
LIG_SH3_2	PAK1_HUMAN	13	18	Binary	Physicochemical compatibility	Phosphorylation of S21 adjacent to the SH3-binding motif of Serine/threonine-protein kinase PAK 1 (PAK1) by RAC subfamily inhibits binding to Cytoplasmic protein NCK1 (NCK1), which regulates its localization to focal contacts.	details	Inferred