switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:LIG_TYR_ITIM (7 hits) x

x Coloured by: Modifier evidence source
Curated inferred

x Index

Proto-oncogene tyrosine-protein kinase Src	Tyrosine-protein kinase Blk	Tyrosine-protein kinase Fyn
Tyrosine-protein kinase Lyn

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Protein

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Information

Evidence

Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens
LIG_TYR_ITIM	OX1R_HUMAN	356	361	Avidity‑sensing		Orexin-A induced phosphorylation of the ITSM and ITIM motifs in Orexin receptor type 1 (HCRTR1) allows binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via its two SH2 domains. Mutation of either tyrosine in the motifs abolishes binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).	details	Inferred
LIG_TYR_ITIM	OX1R_HUMAN	356	361	Avidity‑sensing		Orexin-A induced phosphorylation of the ITSM and ITIM motifs in Orexin receptor type 1 (HCRTR1) allows binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via its two SH2 domains. Mutation of either tyrosine in the motifs abolishes binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).	details	Inferred
Tyrosine-protein kinase Blk - BLK - Homo sapiens
LIG_TYR_ITIM	FCG2B_HUMAN	290	295	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the ITIM motif of Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) induces binding of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) via its SH2 domain.	details	Inferred
LIG_TYR_ITIM	FCG2B_HUMAN	290	295	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the ITIM motif of Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) induces binding of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) via its SH2 domain.	details	Inferred
Tyrosine-protein kinase Fyn - FYN - Homo sapiens
LIG_TYR_ITIM	FCG2B_HUMAN	290	295	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the ITIM motif of Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) induces binding of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) via its SH2 domain.	details	Inferred
Tyrosine-protein kinase Lyn - LYN - Homo sapiens
LIG_TYR_ITIM	FCG2B_HUMAN	290	295	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the ITIM motif of Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) induces binding of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) via its SH2 domain.	details	Inferred
LIG_TYR_ITIM	FCG2B_HUMAN	290	295	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the ITIM motif of Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) induces binding of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) via its SH2 domain.	details	Inferred