switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:LIG_TYR_ITSM (8 hits) x

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Curated inferred

x Index

Proto-oncogene tyrosine-protein kinase Src

Tyrosine-protein kinase Fyn

Tyrosine-protein kinase Lyn

Motif

Protein

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Evidence

Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens
LIG_TYR_ITSM	OX1R_HUMAN	79	86	Avidity‑sensing		Orexin-A induced phosphorylation of the ITSM and ITIM motifs in Orexin receptor type 1 (HCRTR1) allows binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via its two SH2 domains. Mutation of either tyrosine in the motifs abolishes binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).	details	Inferred
LIG_TYR_ITSM	OX1R_HUMAN	79	86	Avidity‑sensing		Orexin-A induced phosphorylation of the ITSM and ITIM motifs in Orexin receptor type 1 (HCRTR1) allows binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via its two SH2 domains. Mutation of either tyrosine in the motifs abolishes binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).	details	Inferred
Tyrosine-protein kinase Fyn - FYN - Homo sapiens
LIG_TYR_ITSM	SLAF1_HUMAN	277	284	Binary	Physicochemical compatibility	Phosphorylation of Y281 in the ITSM motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via one of its SH2 domains.	details	Inferred
LIG_TYR_ITSM	SLAF1_HUMAN	277	284	Binary	Physicochemical compatibility	Phosphorylation of Y281 in the ITSM motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via one of its SH2 domains.	details	Inferred
LIG_TYR_ITSM	SLAF1_HUMAN	323	330	Binary	Physicochemical compatibility	Phosphorylation of Y327 in the ITSM motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via one of its SH2 domains.	details	Inferred
LIG_TYR_ITSM	SLAF1_HUMAN	323	330	Binary	Physicochemical compatibility	Phosphorylation of Y327 in the ITSM motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via one of its SH2 domains.	details	Inferred
Tyrosine-protein kinase Lyn - LYN - Homo sapiens
LIG_TYR_ITSM	SLAF1_HUMAN	323	330	Binary	Physicochemical compatibility	Phosphorylation of Y327 in the ITSM motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via one of its SH2 domains.	details	Inferred
LIG_TYR_ITSM	SLAF1_HUMAN	323	330	Binary	Physicochemical compatibility	Phosphorylation of Y327 in the ITSM motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via one of its SH2 domains.	details	Inferred