switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:TRG_ENDOCYTIC_2 (9 hits) x

x Coloured by: Modifier evidence source
Curated inferred

x Index

AP2-associated protein kinase 1	Cyclin-dependent kinase 5 (Mus)	Proto-oncogene tyrosine-protein kinase LCK (Mus)
Proto-oncogene tyrosine-protein kinase Src	Tyrosine-protein kinase Fyn (Mus)	Tyrosine-protein kinase JAK2
Tyrosine-protein kinase Lck

Motif

Protein

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Evidence

AP2-associated protein kinase 1 - AAK1 - Homo sapiens
TRG_ENDOCYTIC_2	PPAL_HUMAN	413	416	Uncategorised	Uncategorised	Phosphorylation of T156 in AP-2 complex subunit mu (AP2M1) by AP2-associated protein kinase 1 (AAK1) upon clathrin recruitment strengthens the interaction between AP-2 complex subunit mu (AP2M1) and cargo proteins.	details	Curated
Cyclin-dependent kinase 5 - CDK5 - Mus musculus
TRG_ENDOCYTIC_2	PI51C_HUMAN	649	652	Binary	Physicochemical compatibility	Phosphorylation of S645 near the AP2-binding motif of Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) by Cyclin-dependent kinase 5 (Cdk5) inhibits its interaction with AP-2 complex subunit mu (AP2M1).	details	Curated
Proto-oncogene tyrosine-protein kinase LCK - LCK - Mus musculus
TRG_ENDOCYTIC_2	CTLA4_MOUSE	201	204	Specificity	Altered binding specificity	Dephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4.	details	Inferred
Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens
TRG_ENDOCYTIC_2	L1CAM_HUMAN	1176	1179	Binary	Physicochemical compatibility	Phosphorylation of Y1176 by Proto-oncogene tyrosine-protein kinase Src (SRC) in the endocytosis motif of Neural cell adhesion molecule L1 (L1CAM) inhibits binding to AP-2 complex subunit mu (AP2M1).	details	Curated
TRG_ENDOCYTIC_2	L1CAM_HUMAN	1176	1179	Binary	Physicochemical compatibility	Phosphorylation of Y1176 in the endocytotic motif of Neural cell adhesion molecule L1 (L1CAM) by Proto-oncogene tyrosine-protein kinase Src (SRC) abolishes binding to the AP-2 complex subunit mu (AP2M1) and thereby inhibits internalisation of Neural cell adhesion molecule L1 (L1CAM).	details	Curated
Tyrosine-protein kinase Fyn - FYN - Mus musculus
TRG_ENDOCYTIC_2	CTLA4_MOUSE	201	204	Specificity	Altered binding specificity	Dephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4.	details	Inferred
Tyrosine-protein kinase JAK2 - JAK2 - Homo sapiens
TRG_ENDOCYTIC_2	CTLA4_MOUSE	201	204	Specificity	Altered binding specificity	Dephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4.	details	Inferred
TRG_ENDOCYTIC_2	CTLA4_MOUSE	201	204	Specificity	Altered binding specificity	Dephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4.	details	Inferred
Tyrosine-protein kinase Lck - LCK - Homo sapiens
TRG_ENDOCYTIC_2	CTLA4_MOUSE	201	204	Specificity	Altered binding specificity	Dephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4.	details	Inferred