Casein kinase II subunit alpha - CSNK2A1 - Homo sapiens |
| LIG_FHA_2 | XRCC1_HUMAN | 521 | 527 | Binary | Physicochemical compatibility | Phosphorylation of T523 in the FHA-binding motif of DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1) induces binding to the Aprataxin (APTX) protein. | details | Curated |
Casein kinase II subunit alpha' - CSNK2A2 - Homo sapiens |
| LIG_FHA_2 | XRCC1_HUMAN | 521 | 527 | Binary | Physicochemical compatibility | Phosphorylation of T523 in the FHA-binding motif of DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1) induces binding to the Aprataxin (APTX) protein. | details | Inferred |
Cyclin-dependent kinase 1 - CDK1 - Homo sapiens |
| LIG_FHA_2 | MK67I_HUMAN | 238 | 244 | Specificity | Altered binding specificity | Phosphorylation of T238 of MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by GSK3B. Triple-phosphorylated hNIFK (MKI67IP) binds strongly to Antigen KI-67 (MKI67). | details | Curated |
DNA-dependent protein kinase catalytic subunit - PRKDC - Homo sapiens |
| LIG_FHA_1 | CHK2_HUMAN | 66 | 72 | Binary | Physicochemical compatibility | Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein. | details | Inferred |
Dual specificity protein kinase TTK - TTK - Homo sapiens |
| LIG_FHA_1 | CHK2_HUMAN | 66 | 72 | Binary | Physicochemical compatibility | Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein. | details | Inferred |
| LIG_FHA_1 | CHK2_HUMAN | 66 | 72 | Binary | Physicochemical compatibility | Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein. | details | Inferred |
Glycogen synthase kinase-3 alpha - GSK3A - Homo sapiens |
| LIG_FHA_2 | MK67I_HUMAN | 238 | 244 | Specificity | Altered binding specificity | Phosphorylation of T238 of MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by GSK3B. Triple-phosphorylated hNIFK (MKI67IP) binds strongly to Antigen KI-67 (MKI67). | details | Inferred |
| LIG_FHA_2 | MK67I_HUMAN | 238 | 244 | Specificity | Altered binding specificity | Phosphorylation of T238 of MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by GSK3B. Triple-phosphorylated hNIFK (MKI67IP) binds strongly to Antigen KI-67 (MKI67). | details | Inferred |
| LIG_FHA_2 | MK67I_HUMAN | 238 | 244 | Specificity | Altered binding specificity | Phosphorylation of T238 of MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by GSK3B. Triple-phosphorylated hNIFK (MKI67IP) binds strongly to Antigen KI-67 (MKI67). | details | Inferred |
| LIG_FHA_2 | MK67I_HUMAN | 238 | 244 | Specificity | Altered binding specificity | Phosphorylation of T238 of MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by GSK3B. Triple-phosphorylated hNIFK (MKI67IP) binds strongly to Antigen KI-67 (MKI67). | details | Inferred |
| LIG_FHA_2 | MK67I_HUMAN | 238 | 244 | Cumulative | Rheostatic | Phosphorylation of T238 in MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by Glycogen synthase kinase-3 beta (GSK3B). Triple-phosphorylated hNIFK (MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)) binds strongly to Antigen KI-67 (MKI67). See also switch details | details | Inferred |
| LIG_FHA_2 | MK67I_HUMAN | 238 | 244 | Cumulative | Rheostatic | Phosphorylation of T238 in MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by Glycogen synthase kinase-3 beta (GSK3B). Triple-phosphorylated hNIFK (MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)) binds strongly to Antigen KI-67 (MKI67). See also switch details | details | Inferred |
| LIG_FHA_2 | MK67I_HUMAN | 238 | 244 | Cumulative | Rheostatic | Phosphorylation of T238 in MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by Glycogen synthase kinase-3 beta (GSK3B). Triple-phosphorylated hNIFK (MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)) binds strongly to Antigen KI-67 (MKI67). See also switch details | details | Inferred |
| LIG_FHA_2 | MK67I_HUMAN | 238 | 244 | Cumulative | Rheostatic | Phosphorylation of T238 in MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by Glycogen synthase kinase-3 beta (GSK3B). Triple-phosphorylated hNIFK (MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)) binds strongly to Antigen KI-67 (MKI67). See also switch details | details | Inferred |
Glycogen synthase kinase-3 beta - GSK3B - Homo sapiens |
| LIG_FHA_2 | MK67I_HUMAN | 238 | 244 | Specificity | Altered binding specificity | Phosphorylation of T238 of MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by GSK3B. Triple-phosphorylated hNIFK (MKI67IP) binds strongly to Antigen KI-67 (MKI67). | details | Curated |
| LIG_FHA_2 | MK67I_HUMAN | 238 | 244 | Specificity | Altered binding specificity | Phosphorylation of T238 of MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by GSK3B. Triple-phosphorylated hNIFK (MKI67IP) binds strongly to Antigen KI-67 (MKI67). | details | Curated |
| LIG_FHA_2 | MK67I_HUMAN | 238 | 244 | Cumulative | Rheostatic | Phosphorylation of T238 in MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by Glycogen synthase kinase-3 beta (GSK3B). Triple-phosphorylated hNIFK (MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)) binds strongly to Antigen KI-67 (MKI67). See also switch details | details | Curated |
| LIG_FHA_2 | MK67I_HUMAN | 238 | 244 | Cumulative | Rheostatic | Phosphorylation of T238 in MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by Glycogen synthase kinase-3 beta (GSK3B). Triple-phosphorylated hNIFK (MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)) binds strongly to Antigen KI-67 (MKI67). See also switch details | details | Curated |
Mitogen-activated protein kinase kinase kinase MLT - MLTK - Homo sapiens |
| LIG_FHA_1 | CHK2_HUMAN | 66 | 72 | Binary | Physicochemical compatibility | Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein. | details | Inferred |
NP_000042 - ? - ? |
| LIG_FHA_1 | CHK2_HUMAN | 66 | 72 | Binary | Physicochemical compatibility | Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein. | details | Inferred |
Probable serine/threonine-protein kinase pknG - PKNG - Mycobacterium tuberculosis |
| LIG_FHA_1 | Y1827_MYCTU | 19 | 25 | Binary | Physicochemical compatibility | Phosphorylation of T21 in the FHA-binding motif of Uncharacterized protein Rv1827/MT1875 (Rv1827) by Probable serine/threonine-protein kinase pknG (pknG) results in auto-inhibition due to an intramolecular interaction with the FHA domain. As a result, phosphorylation-independent interactions of the FHA domain with metabolic enzymes, which regulate the catalytic activity of these enzymes, are blocked (See also switch details). | details | Curated |
Serine-protein kinase ATM - ATM - Homo sapiens |
| LIG_FHA_1 | CHK2_HUMAN | 66 | 72 | Binary | Physicochemical compatibility | Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein. | details | Inferred |
Serine/threonine-protein kinase ATR - ATR - Homo sapiens |
| LIG_FHA_1 | CHK2_HUMAN | 66 | 72 | Binary | Physicochemical compatibility | Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein. | details | Inferred |
Serine/threonine-protein kinase Chk2 - CHEK2 - Homo sapiens |
| LIG_FHA_1 | CHK2_HUMAN | 66 | 72 | Binary | Physicochemical compatibility | Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein. | details | Inferred |
| LIG_FHA_1 | CHK2_HUMAN | 66 | 72 | Binary | Physicochemical compatibility | Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein. | details | Inferred |
Serine/threonine-protein kinase PLK1 - PLK1 - Homo sapiens |
| LIG_FHA_1 | CHK2_HUMAN | 66 | 72 | Binary | Physicochemical compatibility | Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein. | details | Inferred |
| LIG_FHA_1 | CHK2_HUMAN | 66 | 72 | Binary | Physicochemical compatibility | Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein. | details | Inferred |
Serine/threonine-protein kinase pknB - PKNB - Mycobacterium tuberculosis |
| LIG_FHA_1 | Y1827_MYCTU | 20 | 26 | Binary | Physicochemical compatibility | Phosphorylation of T22 in the FHA-binding motif of Uncharacterized protein Rv1827/MT1875 (Rv1827) by Serine/threonine-protein kinase pknB (pknB) results in auto-inhibition due to an intramolecular interaction with the FHA domain. As a result, phosphorylation-independent interactions of the FHA domain with metabolic enzymes, which regulate the catalytic activity of these enzymes, are blocked (See also switch details). | details | Curated |
