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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: PFAM:PF00640 (25 hits) x
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          Curated          inferred


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3-phosphoinositide-dependent protein kinase 1Cyclin-dependent kinase 1Glycogen synthase kinase-3 beta
High affinity nerve growth factor receptorInsulin receptorProto-oncogene tyrosine-protein kinase Src
Tyrosine-protein kinase FynTyrosine-protein kinase SYK


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

3-phosphoinositide-dependent protein kinase 1 - PDPK1 -  Homo sapiens
LIG_PTB_Phospho_1 ITB3_HUMAN779785BinaryPhysicochemical compatibilityPhosphorylation of T779 in the PTB-binding motif of Integrin beta-3 (ITGB3) inhibits its interaction with SHC-transforming protein 1 (SHC1).
details
Inferred

Cyclin-dependent kinase 1 - CDK1 -  Homo sapiens
LIG_PTB_Apo_2 A4_HUMAN756763BinaryPhysicochemical compatibilityPhosphorylation of T743 adjacent to the PTB-binding motif of Amyloid beta A4 protein (APP) reduces the affinity for Amyloid beta A4 precursor protein-binding family B member 1 (APBB1).
details
Inferred

Glycogen synthase kinase-3 beta - GSK3B -  Homo sapiens
LIG_PTB_Apo_2 A4_HUMAN756763BinaryPhysicochemical compatibilityPhosphorylation of T743 adjacent to the PTB-binding motif of Amyloid beta A4 protein (APP) reduces the affinity for Amyloid beta A4 precursor protein-binding family B member 1 (APBB1).
details
Inferred

High affinity nerve growth factor receptor - NTRK1 -  Homo sapiens
LIG_PTB_Phospho_1 NTRK1_HUMAN490496BinaryPhysicochemical compatibilityPhosphorylation of Y496 in the PTB-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred
LIG_PTB_Phospho_1 NTRK1_HUMAN490496BinaryPhysicochemical compatibilityPhosphorylation of Y496 in the PTB-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred
LIG_PTB_Phospho_1 NTRK1_HUMAN490496BinaryPhysicochemical compatibilityPhosphorylation of Y496 in the PTB-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred

Insulin receptor - INSR -  Homo sapiens
LIG_PTB_Phospho_1 INSR_HUMAN993999BinaryPhysicochemical compatibilityPhosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred
LIG_PTB_Phospho_1 INSR_HUMAN993999BinaryPhysicochemical compatibilityPhosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred
LIG_PTB_Phospho_1 INSR_HUMAN993999BinaryPhysicochemical compatibilityPhosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred
LIG_PTB_Phospho_1 INSR_HUMAN993999BinaryPhysicochemical compatibilityPhosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred

Proto-oncogene tyrosine-protein kinase Src - SRC -  Homo sapiens
LIG_PTB_Phospho_1 ITB3_HUMAN779785BinaryPhysicochemical compatibilityPhosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred
LIG_PTB_Phospho_1 ITB3_HUMAN779785BinaryPhysicochemical compatibilityPhosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred
LIG_PTB_Phospho_1 LRP1_HUMAN45014507BinaryPhysicochemical compatibilityPhosphorylation of Y4507 in the PTB-binding motif of Prolow-density lipoprotein receptor-related protein 1 (LRP1) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred
LIG_PTB_Phospho_1 LRP1_HUMAN45014507BinaryPhysicochemical compatibilityPhosphorylation of Y4507 in the PTB-binding motif of Prolow-density lipoprotein receptor-related protein 1 (LRP1) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred
LIG_PTB_Phospho_1 ITB3_HUMAN779785CumulativeRheostaticWhile phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction.
details
Inferred
LIG_PTB_Phospho_1 ITB3_HUMAN779785CumulativeRheostaticWhile phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction.
details
Inferred
LIG_PTB_Phospho_1 ITB3_HUMAN779785CumulativeRheostaticWhile phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction.
details
Inferred
LIG_PTB_Phospho_1 ITB3_HUMAN779785CumulativeRheostaticWhile phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction.
details
Inferred
LIG_PTB_Phospho_1 ITB3_HUMAN779785CumulativeRheostaticWhile phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction.
details
Inferred
LIG_PTB_Phospho_1 ITB3_HUMAN779785SpecificityAltered binding specificityPhosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1).
details
Inferred
LIG_PTB_Phospho_1 ITB3_HUMAN779785SpecificityAltered binding specificityPhosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1).
details
Inferred

Tyrosine-protein kinase Fyn - FYN -  Homo sapiens
LIG_PTB_Apo_2 A4_HUMAN756763SpecificityAltered binding specificityPhosphorylation of Y757 in APP (Amyloid beta A4 protein (APP)) switches its specificity from PTB domain containing proteins, like Amyloid beta A4 precursor protein-binding family B member 1 (APBB1), which is involved in trafficking and processing of APP, to SH2 domain containing proteins, such as Growth factor receptor-bound protein 2 (GRB2).
details
Inferred

Tyrosine-protein kinase SYK - SYK -  Homo sapiens
LIG_PTB_Phospho_1 ITB3_HUMAN779785BinaryPhysicochemical compatibilityPhosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred
LIG_PTB_Phospho_1 ITB3_HUMAN779785CumulativeRheostaticWhile phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction.
details
Inferred
LIG_PTB_Phospho_1 ITB3_HUMAN779785SpecificityAltered binding specificityPhosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1).
details
Inferred
           
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