About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: PFAM:PF08389 (5 hits) x
submit


x  Coloured by: Modifier evidence source
          Curated          inferred


x  Index
Serine/threonine-protein kinase CBK1 (Saccharomyces)Serine/threonine-protein kinase PLK1Serine/threonine-protein kinase PLK3


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Serine/threonine-protein kinase CBK1 - CBK1 -  Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
TRG_NES ACE2_YEAST122150BinaryPhysicochemical compatibilityPhosphorylation of S137 in the NES of Metallothionein expression activator (ACE2) inhibits binding to Exportin-1 (CRM1). Phosphorylation of S137, and to a lesser extent S122, by Cbk1 directly antagonizes the interaction of Ace2 with nuclear export machinery.
details
Curated
TRG_NES ACE2_YEAST122150BinaryPhysicochemical compatibilityPhosphorylation of S122 in the NES of Metallothionein expression activator (ACE2) inhibits binding to Exportin-1 (CRM1). Phosphorylation of S137, and to a lesser extent S122, by Cbk1 directly antagonizes the interaction of Ace2 with nuclear export machinery.
details
Curated

Serine/threonine-protein kinase PLK1 - PLK1 -  Homo sapiens
TRG_NES_CRM1_1 MPIP3_HUMAN189203BinaryPhysicochemical compatibilityPhosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C).
details
Curated

Serine/threonine-protein kinase PLK3 - PLK3 -  Homo sapiens
TRG_NES_CRM1_1 MPIP3_HUMAN189203BinaryPhysicochemical compatibilityPhosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C).
details
Inferred
TRG_NES_CRM1_1 MPIP3_HUMAN189203BinaryPhysicochemical compatibilityPhosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C).
details
Inferred
           
Please send any suggestions/comments to: switches@elm.eu.org