switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:O95644 (7 hits) x

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Curated inferred

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Glycogen synthase kinase-3 beta	cAMP subfamily ()	cAMP-dependent protein kinase catalytic subunit alpha
cAMP-dependent protein kinase catalytic subunit alpha (Mus)

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Protein

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Evidence

cAMP subfamily
MOD_GSK3_1	NFAC1_HUMAN	287	294	Binary	Physicochemical compatibility	Phosphorylation of S294 adjacent to the NLS of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by cAMP subfamily primes Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) for subsequent phosphorylation by Glycogen synthase kinase-3 beta (GSK3B), which results in inhibition of nuclear import of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1).	details	Curated
MOD_GSK3_1	NFAC1_HUMAN	238	245	Binary	Physicochemical compatibility	Phosphorylation of S245 adjacent to the NLS of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by cAMP subfamily primes Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) for subsequent phosphorylation by Glycogen synthase kinase-3 beta (GSK3B), which results in inhibition of nuclear import of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1).	details	Curated
Glycogen synthase kinase-3 beta - GSK3B - Homo sapiens
TRG_NLS_MonoExtN_4	NFAC1_HUMAN	262	269	Binary	Physicochemical compatibility	Phosphorylation of S241 and S290 adjacent to the NLS of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by Glycogen synthase kinase-3 beta (GSK3B) and Glycogen synthase kinase-3 beta (GSK3B) inhibits nuclear import of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by disrupting its interaction with Importin subunit alpha-2 (KPNA2). Calcium-dependent dephosphorylation by calcineurin promotes nuclear import.	details	Curated
TRG_NLS_MonoExtN_4	NFAC1_HUMAN	262	269	Binary	Physicochemical compatibility	Phosphorylation of S241 and S290 adjacent to the NLS of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by Glycogen synthase kinase-3 beta (GSK3B) and Glycogen synthase kinase-3 beta (GSK3B) inhibits nuclear import of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by disrupting its interaction with Importin subunit alpha-2 (KPNA2). Calcium-dependent dephosphorylation by calcineurin promotes nuclear import.	details	Curated
cAMP-dependent protein kinase catalytic subunit alpha - PRKACA - Homo sapiens
MOD_GSK3_1	NFAC1_HUMAN	287	294	Binary	Physicochemical compatibility	Phosphorylation of S294 adjacent to the NLS of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by cAMP subfamily primes Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) for subsequent phosphorylation by Glycogen synthase kinase-3 beta (GSK3B), which results in inhibition of nuclear import of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1).	details	Inferred
MOD_GSK3_1	NFAC1_HUMAN	238	245	Binary	Physicochemical compatibility	Phosphorylation of S245 adjacent to the NLS of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by cAMP subfamily primes Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) for subsequent phosphorylation by Glycogen synthase kinase-3 beta (GSK3B), which results in inhibition of nuclear import of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1).	details	Inferred
cAMP-dependent protein kinase catalytic subunit alpha - PRKACA - Mus musculus
MOD_GSK3_1	NFAC1_HUMAN	238	245	Binary	Physicochemical compatibility	Phosphorylation of S245 adjacent to the NLS of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by cAMP subfamily primes Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) for subsequent phosphorylation by Glycogen synthase kinase-3 beta (GSK3B), which results in inhibition of nuclear import of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1).	details	Inferred