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5'-AMP-activated protein kinase catalytic subunit alpha-1Aurora kinase ACasein kinase I isoform alpha
Casein kinase I isoform deltaCasein kinase I subfamily ()Cyclin-dependent kinase 1
Cyclin-dependent kinase 2Cyclin-dependent kinase 5Cyclin-dependent kinase 7
Cyclin-dependent kinase 9DNA-dependent protein kinase catalytic subunitDeath-associated protein kinase 1
Death-associated protein kinase 3Dual specificity protein kinase TTKDual specificity tyrosine-phosphorylation-regulated kinase 1A
Dual specificity tyrosine-phosphorylation-regulated kinase 2G protein-coupled receptor kinase 5Homeodomain-interacting protein kinase 2
MAP kinase-activated protein kinase 2MAP kinase-activated protein kinase 5Mitogen-activated protein kinase 1
Mitogen-activated protein kinase 1 (Mus)Mitogen-activated protein kinase 14Mitogen-activated protein kinase 3
Mitogen-activated protein kinase 8Mitogen-activated protein kinase 9NP_000042 (?)
NUAK family SNF1-like kinase 1Protein kinase C delta typeSerine-protein kinase ATM
Serine-protein kinase ATM (Mus)Serine/threonine-protein kinase 17ASerine/threonine-protein kinase ATR
Serine/threonine-protein kinase Chk1Serine/threonine-protein kinase Chk2Serine/threonine-protein kinase PLK3
Serine/threonine-protein kinase SMG1Serine/threonine-protein kinase STK11Serine/threonine-protein kinase VRK1
TP53-regulating kinaseTranscription initiation factor TFIID subunit 1


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

5'-AMP-activated protein kinase catalytic subunit alpha-1 - PRKAA1 -  Homo sapiens
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Casein kinase I subfamily
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Curated

Aurora kinase A - AURKA -  Homo sapiens
DOC_WW_Pin1_4 P53_HUMAN312317BinaryPhysicochemical compatibilityPhosphorylation of S315 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
DOC_WW_Pin1_4 P53_HUMAN312317BinaryPhysicochemical compatibilityPhosphorylation of S315 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Casein kinase I isoform alpha - CSNK1A1 -  Homo sapiens
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Casein kinase I isoform delta - CSNK1D -  Homo sapiens
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Cyclin-dependent kinase 1 - CDK1 -  Homo sapiens
DOC_WW_Pin1_4 P53_HUMAN312317BinaryPhysicochemical compatibilityPhosphorylation of S315 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Cyclin-dependent kinase 2 - CDK2 -  Homo sapiens
DOC_WW_Pin1_4 P53_HUMAN312317BinaryPhysicochemical compatibilityPhosphorylation of S315 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred

Cyclin-dependent kinase 5 - CDK5 -  Homo sapiens
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Cyclin-dependent kinase 7 - CDK7 -  Homo sapiens
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Cyclin-dependent kinase 9 - CDK9 -  Homo sapiens
DOC_WW_Pin1_4 P53_HUMAN312317BinaryPhysicochemical compatibilityPhosphorylation of S315 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

DNA-dependent protein kinase catalytic subunit - PRKDC -  Homo sapiens
MOD_GSK3_1 P53_HUMAN3037BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) at S37 primes the protein for phosphorylation at S33 by Glycogen synthase kinase-3 beta (GSK3B).
details
Curated
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Death-associated protein kinase 1 - DAPK1 -  Homo sapiens
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Death-associated protein kinase 3 - DAPK3 -  Homo sapiens
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Dual specificity protein kinase TTK - TTK -  Homo sapiens
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Dual specificity tyrosine-phosphorylation-regulated kinase 1A - DYRK1A -  Homo sapiens
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Dual specificity tyrosine-phosphorylation-regulated kinase 2 - DYRK2 -  Homo sapiens
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

G protein-coupled receptor kinase 5 - GRK5 -  Homo sapiens
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred

Homeodomain-interacting protein kinase 2 - HIPK2 -  Homo sapiens
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

MAP kinase-activated protein kinase 2 - MAPKAPK2 -  Homo sapiens
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

MAP kinase-activated protein kinase 5 - MAPKAPK5 -  Homo sapiens
MOD_GSK3_1 P53_HUMAN3037BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) at S37 primes the protein for phosphorylation at S33 by Glycogen synthase kinase-3 beta (GSK3B).
details
Inferred
MOD_GSK3_1 P53_HUMAN3037BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) at S37 primes the protein for phosphorylation at S33 by Glycogen synthase kinase-3 beta (GSK3B).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Mitogen-activated protein kinase 1 - MAPK1 -  Homo sapiens
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Mitogen-activated protein kinase 1 - MAPK1 -  Mus musculus
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Mitogen-activated protein kinase 14 - MAPK14 -  Homo sapiens
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Mitogen-activated protein kinase 3 - MAPK3 -  Homo sapiens
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Mitogen-activated protein kinase 8 - MAPK8 -  Homo sapiens
DOC_WW_Pin1_4 P53_HUMAN7883BinaryPhysicochemical compatibilityPhosphorylation of T81 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Mitogen-activated protein kinase 9 - MAPK9 -  Homo sapiens
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

NP_000042 - ? -  ?
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

NUAK family SNF1-like kinase 1 - NUAK1 -  Homo sapiens
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Protein kinase C delta type - PRKCD -  Homo sapiens
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Serine-protein kinase ATM - ATM -  Homo sapiens
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Serine-protein kinase ATM - ATM -  Mus musculus
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Serine/threonine-protein kinase 17A - STK17A -  Homo sapiens
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Serine/threonine-protein kinase ATR - ATR -  Homo sapiens
MOD_GSK3_1 P53_HUMAN3037BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) at S37 primes the protein for phosphorylation at S33 by Glycogen synthase kinase-3 beta (GSK3B).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Serine/threonine-protein kinase Chk1 - CHEK1 -  Homo sapiens
MOD_GSK3_1 P53_HUMAN3037BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) at S37 primes the protein for phosphorylation at S33 by Glycogen synthase kinase-3 beta (GSK3B).
details
Inferred
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Serine/threonine-protein kinase Chk2 - CHEK2 -  Homo sapiens
MOD_GSK3_1 P53_HUMAN3037BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) at S37 primes the protein for phosphorylation at S33 by Glycogen synthase kinase-3 beta (GSK3B).
details
Inferred
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Serine/threonine-protein kinase PLK3 - PLK3 -  Homo sapiens
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Serine/threonine-protein kinase SMG1 - SMG1 -  Homo sapiens
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Serine/threonine-protein kinase STK11 - STK11 -  Homo sapiens
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Serine/threonine-protein kinase VRK1 - VRK1 -  Homo sapiens
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Inferred
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Inferred
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

TP53-regulating kinase - TP53RK -  Homo sapiens
LIG_TAZ2 P53_HUMAN1925CumulativeRheostaticMultisite phosphorylation of S15 and T18 and S20 and S33 and S37 and S46 in the TAD region of Cellular tumor antigen p53 (TP53) additively enhances its affinity for CREB-binding protein (CREBBP).
details
Inferred

Transcription initiation factor TFIID subunit 1 - TAF1 -  Homo sapiens
LIG_PH_Tfb1 P53_HUMAN5056CumulativeRheostaticMultisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53).
details
Inferred
           
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