switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P20963 (6 hits) x

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Curated inferred

x Index

Tyrosine-protein kinase Fyn

Tyrosine-protein kinase Lck

Motif

Protein

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Information

Evidence

Tyrosine-protein kinase Fyn - FYN - Homo sapiens
LIG_TYR_ITAM	CD3Z_HUMAN	108	126	Avidity‑sensing	Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred
LIG_TYR_ITAM	CD3Z_HUMAN	108	126	Avidity‑sensing	Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred
LIG_TYR_ITAM	CD3Z_HUMAN	108	126	Avidity‑sensing	Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred
LIG_TYR_ITAM	CD3Z_HUMAN	108	126	Avidity‑sensing	Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred
Tyrosine-protein kinase Lck - LCK - Homo sapiens
LIG_TYR_ITAM	CD3Z_HUMAN	139	156	Avidity‑sensing	Phosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred
LIG_TYR_ITAM	CD3Z_HUMAN	139	156	Avidity‑sensing	Phosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred