switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P43403 (14 hits) x

x Coloured by: Modifier evidence source
Curated inferred

x Index

Tyrosine-protein kinase Fyn

Tyrosine-protein kinase Lck

Tyrosine-protein kinase ZAP-70

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

Tyrosine-protein kinase Fyn - FYN - Homo sapiens
LIG_TYR_ITAM	CD3E_HUMAN	185	202	Specificity	Altered binding specificity	Phosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred
LIG_TYR_ITAM	CD3E_HUMAN	185	202	Specificity	Altered binding specificity	Phosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred
LIG_TYR_ITAM	CD3Z_HUMAN	108	126	Avidity‑sensing		Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred
LIG_TYR_ITAM	CD3Z_HUMAN	108	126	Avidity‑sensing		Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred
LIG_TYR_ITAM	CD3Z_HUMAN	108	126	Avidity‑sensing		Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred
LIG_TYR_ITAM	CD3Z_HUMAN	108	126	Avidity‑sensing		Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred
Tyrosine-protein kinase Lck - LCK - Homo sapiens
LIG_TYR_ITAM	CD3Z_HUMAN	139	156	Avidity‑sensing		Phosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred
LIG_TYR_ITAM	CD3Z_HUMAN	139	156	Avidity‑sensing		Phosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred
LIG_SH2_IIC	ZAP70_HUMAN	284	300	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the SH2-binding motif of Tyrosine-protein kinase ZAP-70 (ZAP70) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.	details	Inferred
LIG_SH2_IIC	ZAP70_HUMAN	284	300	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the SH2-binding motif of Tyrosine-protein kinase ZAP-70 (ZAP70) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.	details	Inferred
LIG_SH2_IIC	ZAP70_HUMAN	284	300	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the SH2-binding motif of Tyrosine-protein kinase ZAP-70 (ZAP70) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.	details	Inferred
Tyrosine-protein kinase ZAP-70 - ZAP70 - Homo sapiens
LIG_SH2_IIC	ZAP70_HUMAN	284	300	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the SH2-binding motif of Tyrosine-protein kinase ZAP-70 (ZAP70) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.	details	Inferred
LIG_SH2_IIC	ZAP70_HUMAN	284	300	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the SH2-binding motif of Tyrosine-protein kinase ZAP-70 (ZAP70) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.	details	Inferred
LIG_SH2_IIC	ZAP70_HUMAN	284	300	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the SH2-binding motif of Tyrosine-protein kinase ZAP-70 (ZAP70) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.	details	Inferred