switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:Q96CW1 (4 hits) x

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Curated inferred

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Evidence

AP2-associated protein kinase 1 - AAK1 - Homo sapiens
TRG_ENDOCYTIC_2	PPAL_HUMAN	413	416	Uncategorised	Uncategorised	Phosphorylation of T156 in AP-2 complex subunit mu (AP2M1) by AP2-associated protein kinase 1 (AAK1) upon clathrin recruitment strengthens the interaction between AP-2 complex subunit mu (AP2M1) and cargo proteins.	details	Curated
Cyclin-dependent kinase 5 - CDK5 - Mus musculus
TRG_ENDOCYTIC_2	PI51C_HUMAN	649	652	Binary	Physicochemical compatibility	Phosphorylation of S645 near the AP2-binding motif of Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) by Cyclin-dependent kinase 5 (Cdk5) inhibits its interaction with AP-2 complex subunit mu (AP2M1).	details	Curated
Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens
TRG_ENDOCYTIC_2	L1CAM_HUMAN	1176	1179	Binary	Physicochemical compatibility	Phosphorylation of Y1176 by Proto-oncogene tyrosine-protein kinase Src (SRC) in the endocytosis motif of Neural cell adhesion molecule L1 (L1CAM) inhibits binding to AP-2 complex subunit mu (AP2M1).	details	Curated
TRG_ENDOCYTIC_2	L1CAM_HUMAN	1176	1179	Binary	Physicochemical compatibility	Phosphorylation of Y1176 in the endocytotic motif of Neural cell adhesion molecule L1 (L1CAM) by Proto-oncogene tyrosine-protein kinase Src (SRC) abolishes binding to the AP-2 complex subunit mu (AP2M1) and thereby inhibits internalisation of Neural cell adhesion molecule L1 (L1CAM).	details	Curated