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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: ELM:LIG_PCNA_PIPBox_1 (3 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
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  Physicochemical compatibility  Pre-translational  Competition

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LIG_PCNA_PIPBox_1


ProteinStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

LIG_PCNA_PIPBox_1 - The PCNA binding PIP box motif is found in proteins involved in DNA replication, repair and cell cycle control.
DPOD3_HUMAN456465BinaryPhysicochemical compatibilityPhosphorylation of S458 in the PCNA-binding motif of DNA polymerase delta subunit 3 (POLD3) by cAMP subfamily reduces the affinity of binding to the Proliferating cell nuclear antigen (PCNA) and decreases the processivity of the polymerase complex.
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CDN1A_HUMAN144153BinaryPhysicochemical compatibilityPhosphorylation of T145 in the PCNA-binding motif of Cyclin-dependent kinase inhibitor 1 (CDKN1A) by RAC-alpha serine/threonine-protein kinase (AKT1) inhibits binding to Proliferating cell nuclear antigen (PCNA). As a result, Cyclin-dependent kinase inhibitor 1 (CDKN1A) no longer inhibits Proliferating cell nuclear antigen (PCNA) and blocking of DNA replication is relieved.
details
CDN1A_HUMAN144153BinaryPhysicochemical compatibilityPhosphorylation of S146 in the PCNA-binding motif of Cyclin-dependent kinase inhibitor 1 (CDKN1A) by PKC subfamily inhibits binding to Proliferating cell nuclear antigen (PCNA). As a result, Cyclin-dependent kinase inhibitor 1 (CDKN1A) no longer inhibits Proliferating cell nuclear antigen (PCNA) and blocking of DNA replication is relieved.
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