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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:Q05397 (4 hits) x
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x  Coloured by switch type.
  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
DOC_WW_Pin1_4LIG_FAT_LD_1LIG_SH2_IA
LIG_SH2_SRC


ProteinStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

DOC_WW_Pin1_4 - The Class IV WW domain interaction motif is recognised primarily by the Pin1 phosphorylation-dependent prolyl isomerase.
FAK1_HUMAN907912BinaryPhysicochemical compatibilityPhosphorylation of S910 in the Pin1-binding motif of Focal adhesion kinase 1 (PTK2) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
details

LIG_FAT_LD_1 - The paxillin LD motif is recognized by FAK and other focal adhesion proteins mainly involved in cytoskeletal regulation
PAXI_HUMAN412BinaryPre‑translationalAlternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).
details

LIG_SH2_IA -
FAK1_HUMAN389405BinaryPhysicochemical compatibilityPhosphorylation of Y397 in the SH2-binding motif of Focal adhesion kinase 1 (PTK2) induces binding to the Cytoplasmic protein NCK2 (NCK2) protein.
details

LIG_SH2_SRC - Src-family Src Homology 2 (SH2) domains binding motif.
FAK1_HUMAN397400BinaryPhysicochemical compatibilityPhosphorylation of Y397 in the SH2-binding motif of Focal adhesion kinase 1 (PTK2) induces binding to Neuronal proto-oncogene tyrosine-protein kinase Src (Src).
details
           
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