switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Show inferred Group Index Colouring Info Filtered: ELM:LIG_SH2_STAT5 (7 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

DAP12 interactions	ErbB signaling pathway	NF-kappa B signaling pathway
Natural killer cell mediated cytotoxicity	T cell receptor signaling pathway	TCR signaling

Motif

Protein

Start

End

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Information

Evidence

DAP12 interactions (Reactome - 2172127)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated
ErbB signaling pathway (KEGG - hsa04012)
LIG_SH2_STAT5	GAB1_HUMAN	472	475	Binary	Physicochemical compatibility	Phosphorylation of Y472 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).	details	Curated
LIG_SH2_STAT5	GAB1_HUMAN	447	450	Binary	Physicochemical compatibility	Phosphorylation of Y447 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).	details	Curated
NF-kappa B signaling pathway (KEGG - hsa04064)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated
Natural killer cell mediated cytotoxicity (KEGG - hsa04650)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated
T cell receptor signaling pathway (KEGG - hsa04660)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated
TCR signaling (Reactome - 202403)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated