switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Show inferred Group Index Colouring Info Filtered: UNIPROT:P19174 (7 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Calcium signaling pathway	DAP12 interactions	ErbB signaling pathway
NF-kappa B signaling pathway	Natural killer cell mediated cytotoxicity	T cell receptor signaling pathway
TCR signaling

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

Calcium signaling pathway (KEGG - hsa04020)
LIG_SH2_SRC	EGFR_HUMAN	1016	1019	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1).	details	Curated
DAP12 interactions (Reactome - 2172127)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated
ErbB signaling pathway (KEGG - hsa04012)
LIG_SH2_SRC	EGFR_HUMAN	1016	1019	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1).	details	Curated
NF-kappa B signaling pathway (KEGG - hsa04064)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated
Natural killer cell mediated cytotoxicity (KEGG - hsa04650)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated
T cell receptor signaling pathway (KEGG - hsa04660)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated
TCR signaling (Reactome - 202403)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated