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ELM:DEG_SCF_TRCP1_2 (3 hits)
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Index
Circadian rhythm
Hedgehog signaling pathway
Wnt signaling pathway
Motif
Protein
Start
End
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Information
Evidence
Circadian rhythm
(
KEGG - hsa04710
)
DEG_SCF_TRCP1_2
YAP1_HUMAN
383
387
Specificity
Altered binding specificity
Phosphorylation of
Yorkie homolog (YAP1)
at S381 by
Serine/threonine-protein kinase LATS1 (LATS1)
(a key regulator of the Hippo Pathway) primes the sequence for phosphorylation by
Casein kinase I isoform epsilon (CSNK1E)
at S384 and S387. This targets
YAP1
to the SCF ubiqutin ligase complex,
F-box/WD repeat-containing protein 1A (BTRC)
, which marks is
YAP1
for subsequent degradation by the proteasomal system. N.B.
Serine/threonine-protein kinase LATS2 (LATS2)
can replace
LATS1
and
Casein kinase I isoform delta (CSNK1D)
can replace
CSNK1E
details
Inferred
Hedgehog signaling pathway
(
KEGG - hsa04340
)
DEG_SCF_TRCP1_2
YAP1_HUMAN
383
387
Specificity
Altered binding specificity
Phosphorylation of
Yorkie homolog (YAP1)
at S381 by
Serine/threonine-protein kinase LATS1 (LATS1)
(a key regulator of the Hippo Pathway) primes the sequence for phosphorylation by
Casein kinase I isoform epsilon (CSNK1E)
at S384 and S387. This targets
YAP1
to the SCF ubiqutin ligase complex,
F-box/WD repeat-containing protein 1A (BTRC)
, which marks is
YAP1
for subsequent degradation by the proteasomal system. N.B.
Serine/threonine-protein kinase LATS2 (LATS2)
can replace
LATS1
and
Casein kinase I isoform delta (CSNK1D)
can replace
CSNK1E
details
Inferred
Wnt signaling pathway
(
KEGG - hsa04310
)
DEG_SCF_TRCP1_2
YAP1_HUMAN
383
387
Specificity
Altered binding specificity
Phosphorylation of
Yorkie homolog (YAP1)
at S381 by
Serine/threonine-protein kinase LATS1 (LATS1)
(a key regulator of the Hippo Pathway) primes the sequence for phosphorylation by
Casein kinase I isoform epsilon (CSNK1E)
at S384 and S387. This targets
YAP1
to the SCF ubiqutin ligase complex,
F-box/WD repeat-containing protein 1A (BTRC)
, which marks is
YAP1
for subsequent degradation by the proteasomal system. N.B.
Serine/threonine-protein kinase LATS2 (LATS2)
can replace
LATS1
and
Casein kinase I isoform delta (CSNK1D)
can replace
CSNK1E
details
Inferred