switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:LIG_PTB_Phospho_1 (10 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

ErbB signaling pathway	Focal adhesion	Insulin signaling pathway
Neurotrophin signaling pathway	PI3K-Akt signaling pathway

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

ErbB signaling pathway (KEGG - hsa04012)
LIG_PTB_Phospho_1	ERBB3_HUMAN	1322	1328	Binary	Physicochemical compatibility	Phosphorylation of Y1328 in the PTB-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.	details	Inferred
Focal adhesion (KEGG - hsa04510)
LIG_PTB_Phospho_1	ITB3_HUMAN	779	785	Binary	Physicochemical compatibility	Phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.	details	Inferred
LIG_PTB_Phospho_1	ITB4_HUMAN	1590	1596	Binary	Physicochemical compatibility	Phosphorylation of Y1596 in the PTB-binding motif of Integrin beta-4 (ITGB4) induces binding to the SHC-transforming protein 1 (SHC1) protein.	details	Inferred
LIG_PTB_Phospho_1	ITB3_HUMAN	779	785	Binary	Physicochemical compatibility	Phosphorylation of T779 in the PTB-binding motif of Integrin beta-3 (ITGB3) inhibits its interaction with SHC-transforming protein 1 (SHC1).	details	Inferred
LIG_PTB_Phospho_1	ITB3_HUMAN	779	785	Cumulative	Rheostatic	While phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction.	details	Inferred
LIG_PTB_Phospho_1	ITB3_HUMAN	767	773	Specificity	Altered binding specificity	Phosphorylation of Y773 in Integrin beta-3 (ITGB3) switches the specificity of ITGB3 from Talin-1 (TLN1) to Docking protein 1 (DOK1), with a 2-fold decrease of the affinity for TLN1 and close to a 400-fold increase of the affinity for DOK1. This switch results in negative regulation of integrin activation.	details	Inferred
LIG_PTB_Phospho_1	ITB3_HUMAN	779	785	Specificity	Altered binding specificity	Phosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1).	details	Inferred
Insulin signaling pathway (KEGG - hsa04910)
LIG_PTB_Phospho_1	INSR_HUMAN	993	999	Binary	Physicochemical compatibility	Phosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein.	details	Inferred
Neurotrophin signaling pathway (KEGG - hsa04722)
LIG_PTB_Phospho_1	NTRK1_HUMAN	490	496	Binary	Physicochemical compatibility	Phosphorylation of Y496 in the PTB-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein.	details	Inferred
PI3K-Akt signaling pathway (KEGG - hsa04151)
LIG_PTB_Phospho_1	IL4RA_HUMAN	491	497	Binary	Physicochemical compatibility	Phosphorylation of Y497 in the PTB-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Insulin receptor substrate 1 (IRS1) protein.	details	Inferred