switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:LIG_SH2_III (14 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

ErbB signaling pathway	Growth hormone receptor signaling	Jak-STAT signaling pathway
Osteoclast differentiation

Motif

Protein

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End

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Information

Evidence

ErbB signaling pathway (KEGG - hsa04012)
LIG_SH2_III	STA5A_HUMAN	686	702	Binary	Physicochemical compatibility	Phosphorylation of Y694 in the SH2-binding motif of Signal transducer and activator of transcription 5A (STAT5A) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details	Curated
Growth hormone receptor signaling (Reactome - 982772)
LIG_SH2_III	STA5A_HUMAN	686	702	Binary	Physicochemical compatibility	Phosphorylation of Y694 in the SH2-binding motif of Signal transducer and activator of transcription 5A (STAT5A) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details	Curated
Jak-STAT signaling pathway (KEGG - hsa04630)
LIG_SH2_III	GHR_HUMAN	428	444	Binary	Physicochemical compatibility	Phosphorylation of Y436 in the SH2-binding motif of Growth hormone receptor (GHR) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details	Inferred
LIG_SH2_III	IL2RB_HUMAN	531	540	Binary	Physicochemical compatibility	Phosphorylation of Y536 in the SH2-binding motif of Interleukin-2 receptor subunit beta (IL2RB) induces binding to the Signal transducer and activator of transcription 5A (STAT5A) protein.	details	Inferred
LIG_SH2_III	IL2RB_HUMAN	528	544	Binary	Physicochemical compatibility	Phosphorylation of Y536 in the SH2-binding motif of Interleukin-2 receptor subunit beta (IL2RB) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details	Inferred
LIG_SH2_III	INGR1_HUMAN	457	461	Binary	Physicochemical compatibility	Phosphorylation of Y457 in the SH2-binding motif of Interferon gamma receptor 1 (IFNGR1) induces binding to the Signal transducer and activator of transcription 1-alpha/beta (STAT1) protein.	details	Inferred
LIG_SH2_III	EPOR_HUMAN	360	376	Binary	Physicochemical compatibility	Phosphorylation of Y368 in the SH2-binding motif of Erythropoietin receptor (EPOR) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details	Inferred
LIG_SH2_III	EPOR_HUMAN	418	434	Binary	Physicochemical compatibility	Phosphorylation of Y426 in the SH2-binding motif of Erythropoietin receptor (EPOR) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details	Inferred
LIG_SH2_III	EPOR_HUMAN	496	508	Binary	Physicochemical compatibility	Phosphorylation of Y504 in the SH2-binding motif of Erythropoietin receptor (EPOR) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details	Inferred
LIG_SH2_III	IL4RA_HUMAN	566	585	Binary	Physicochemical compatibility	Phosphorylation of Y575 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Signal transducer and activator of transcription 6 (STAT6) protein.	details	Inferred
LIG_SH2_III	IL4RA_HUMAN	594	613	Binary	Physicochemical compatibility	Phosphorylation of Y603 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Signal transducer and activator of transcription 6 (STAT6) protein.	details	Inferred
LIG_SH2_III	IL4RA_HUMAN	622	641	Binary	Physicochemical compatibility	Phosphorylation of Y631 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Signal transducer and activator of transcription 6 (STAT6) protein.	details	Inferred
LIG_SH2_III	STA5A_HUMAN	686	702	Binary	Physicochemical compatibility	Phosphorylation of Y694 in the SH2-binding motif of Signal transducer and activator of transcription 5A (STAT5A) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details	Curated
Osteoclast differentiation (KEGG - hsa04380)
LIG_SH2_III	INGR1_HUMAN	457	461	Binary	Physicochemical compatibility	Phosphorylation of Y457 in the SH2-binding motif of Interferon gamma receptor 1 (IFNGR1) induces binding to the Signal transducer and activator of transcription 1-alpha/beta (STAT1) protein.	details	Inferred