Please send any suggestions/comments to: switches@elm.eu.org
| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
T cell receptor signaling pathway (KEGG - hsa04660) | ||||||||
| LIG_SH3_5 | CD3E_HUMAN | 184 | 188 | Binary | Allostery | Ligand binding to the T cell receptor complex TCR-CD3 results in a conformational change that exposes an SH3-binding motif in T-cell surface glycoprotein CD3 epsilon chain (CD3E), resulting in recruitment of Cytoplasmic protein NCK2 (NCK2), involved in T cell activation. | Inferred | |
| LIG_SH3_5 | CD3E_HUMAN | 184 | 188 | Specificity | Altered binding specificity | Phosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70). | Inferred | |