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| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
(Reactome - 2676022) | ||||||||
| LIG_TYR_ITAM | CD79A_MOUSE | 179 | 196 | Avidity‑sensing | Phosphorylation of Y182 and Y193 in the ITAM motif of B-cell antigen receptor complex-associated protein alpha chain (Cd79a) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (Syk). Maximal Syk activation requires both Syk SH2 domains and phosphorylation of both ITAM tyrosine residues. | Curated | ||
| LIG_TYR_ITAM | CD79A_MOUSE | 179 | 196 | Avidity‑sensing | Phosphorylation of Y182 and Y193 in the ITAM motif of B-cell antigen receptor complex-associated protein alpha chain (Cd79a) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (Syk). Maximal Syk activation requires both Syk SH2 domains and phosphorylation of both ITAM tyrosine residues. | Curated | ||
B cell receptor signaling pathway (KEGG - mmu04662) | ||||||||
| LIG_TYR_ITAM | CD79A_MOUSE | 179 | 196 | Avidity‑sensing | Phosphorylation of Y182 and Y193 in the ITAM motif of B-cell antigen receptor complex-associated protein alpha chain (Cd79a) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (Syk). Maximal Syk activation requires both Syk SH2 domains and phosphorylation of both ITAM tyrosine residues. | Curated | ||
| LIG_TYR_ITAM | CD79A_MOUSE | 179 | 196 | Avidity‑sensing | Phosphorylation of Y182 and Y193 in the ITAM motif of B-cell antigen receptor complex-associated protein alpha chain (Cd79a) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (Syk). Maximal Syk activation requires both Syk SH2 domains and phosphorylation of both ITAM tyrosine residues. | Curated | ||
Fc epsilon RI signaling pathway (KEGG - hsa04664) | ||||||||
| LIG_TYR_ITAM | FCERG_HUMAN | 62 | 79 | Avidity‑sensing | Phosphorylation of Y65 and Y76 in the ITAM motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK). | Curated | ||
| LIG_TYR_ITAM | FCERG_HUMAN | 62 | 79 | Avidity‑sensing | Phosphorylation of Y65 and Y76 in the ITAM motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK). | Curated | ||
Fc gamma R-mediated phagocytosis (KEGG - hsa04666) | ||||||||
| LIG_TYR_ITAM | FCG2A_HUMAN | 285 | 307 | Avidity‑sensing | Phosphorylation of Y288 and Y304 in the ITAM motif of Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK). | Curated | ||
| LIG_TYR_ITAM | FCG2A_HUMAN | 285 | 307 | Avidity‑sensing | Phosphorylation of Y288 and Y304 in the ITAM motif of Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK). | Curated | ||
Natural killer cell mediated cytotoxicity (KEGG - hsa04650) | ||||||||
| LIG_TYR_ITAM | FCERG_HUMAN | 62 | 79 | Avidity‑sensing | Phosphorylation of Y65 and Y76 in the ITAM motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK). | Curated | ||
| LIG_TYR_ITAM | FCERG_HUMAN | 62 | 79 | Avidity‑sensing | Phosphorylation of Y65 and Y76 in the ITAM motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK). | Curated | ||
Osteoclast differentiation (KEGG - hsa04380) | ||||||||
| LIG_TYR_ITAM | FCG2A_HUMAN | 285 | 307 | Avidity‑sensing | Phosphorylation of Y288 and Y304 in the ITAM motif of Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK). | Curated | ||
| LIG_TYR_ITAM | FCG2A_HUMAN | 285 | 307 | Avidity‑sensing | Phosphorylation of Y288 and Y304 in the ITAM motif of Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK). | Curated | ||
T cell receptor signaling pathway (KEGG - hsa04660) | ||||||||
| LIG_TYR_ITAM | CD3E_HUMAN | 185 | 202 | Specificity | Altered binding specificity | Phosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70). | Inferred | |
| LIG_TYR_ITAM | CD3Z_HUMAN | 69 | 86 | Avidity‑sensing | Phosphorylation of Y72 and Y83 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
| LIG_TYR_ITAM | CD3Z_HUMAN | 69 | 86 | Avidity‑sensing | Phosphorylation of Y72 and Y83 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
| LIG_TYR_ITAM | CD3Z_HUMAN | 108 | 126 | Avidity‑sensing | Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
| LIG_TYR_ITAM | CD3Z_HUMAN | 108 | 126 | Avidity‑sensing | Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
| LIG_TYR_ITAM | CD3Z_HUMAN | 139 | 156 | Avidity‑sensing | Phosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
| LIG_TYR_ITAM | CD3Z_HUMAN | 139 | 156 | Avidity‑sensing | Phosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
| LIG_TYR_ITAM | CD3G_HUMAN | 157 | 174 | Avidity‑sensing | Phosphorylation of Y160 and Y171 in the ITAM motif of T-cell surface glycoprotein CD3 gamma chain (CD3G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
| LIG_TYR_ITAM | CD3G_HUMAN | 157 | 174 | Avidity‑sensing | Phosphorylation of Y160 and Y171 in the ITAM motif of T-cell surface glycoprotein CD3 gamma chain (CD3G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
TCR signaling (Reactome - 202403) | ||||||||
| LIG_TYR_ITAM | CD3Z_HUMAN | 69 | 86 | Avidity‑sensing | Phosphorylation of Y72 and Y83 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
| LIG_TYR_ITAM | CD3Z_HUMAN | 69 | 86 | Avidity‑sensing | Phosphorylation of Y72 and Y83 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
| LIG_TYR_ITAM | CD3Z_HUMAN | 108 | 126 | Avidity‑sensing | Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
| LIG_TYR_ITAM | CD3Z_HUMAN | 108 | 126 | Avidity‑sensing | Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
| LIG_TYR_ITAM | CD3Z_HUMAN | 139 | 156 | Avidity‑sensing | Phosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
| LIG_TYR_ITAM | CD3Z_HUMAN | 139 | 156 | Avidity‑sensing | Phosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
| LIG_TYR_ITAM | CD3G_HUMAN | 157 | 174 | Avidity‑sensing | Phosphorylation of Y160 and Y171 in the ITAM motif of T-cell surface glycoprotein CD3 gamma chain (CD3G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||
| LIG_TYR_ITAM | CD3G_HUMAN | 157 | 174 | Avidity‑sensing | Phosphorylation of Y160 and Y171 in the ITAM motif of T-cell surface glycoprotein CD3 gamma chain (CD3G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70). | Curated | ||