switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:LIG_TYR_ITIM (3 hits) x

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Curated inferred

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Information

Evidence

B cell receptor signaling pathway (KEGG - hsa04662)
LIG_TYR_ITIM	FCG2B_HUMAN	290	295	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the ITIM motif of Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) induces binding of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) via its SH2 domain.	details	Inferred
Fc gamma R-mediated phagocytosis (KEGG - hsa04666)
LIG_TYR_ITIM	FCG2B_HUMAN	290	295	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the ITIM motif of Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) induces binding of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) via its SH2 domain.	details	Inferred
Natural killer cell mediated cytotoxicity (KEGG - hsa04650)
LIG_TYR_ITIM	KI3L2_HUMAN	396	401	Binary	Physicochemical compatibility	Phosphorylation of Y398 in the ITIM motif of Killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2) induces binding of Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) via one of its SH2 domains.	details	Inferred