switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: PFAM:PF00018 (5 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Axon guidance

ErbB signaling pathway

T cell receptor signaling pathway

Motif

Protein

Start

End

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Information

Evidence

Axon guidance (KEGG - hsa04360)
LIG_SH3_2	PAK1_HUMAN	13	18	Binary	Physicochemical compatibility	Phosphorylation of S21 adjacent to the SH3-binding motif of Serine/threonine-protein kinase PAK 1 (PAK1) by RAC subfamily inhibits binding to Cytoplasmic protein NCK1 (NCK1), which regulates its localization to focal contacts.	details	Inferred
ErbB signaling pathway (KEGG - hsa04012)
LIG_SH3_2	PAK1_HUMAN	13	18	Binary	Physicochemical compatibility	Phosphorylation of S21 adjacent to the SH3-binding motif of Serine/threonine-protein kinase PAK 1 (PAK1) by RAC subfamily inhibits binding to Cytoplasmic protein NCK1 (NCK1), which regulates its localization to focal contacts.	details	Inferred
T cell receptor signaling pathway (KEGG - hsa04660)
LIG_SH3_2	PAK1_HUMAN	13	18	Binary	Physicochemical compatibility	Phosphorylation of S21 adjacent to the SH3-binding motif of Serine/threonine-protein kinase PAK 1 (PAK1) by RAC subfamily inhibits binding to Cytoplasmic protein NCK1 (NCK1), which regulates its localization to focal contacts.	details	Inferred
LIG_SH3_5	CD3E_HUMAN	184	188	Binary	Allostery	Ligand binding to the T cell receptor complex TCR-CD3 results in a conformational change that exposes an SH3-binding motif in T-cell surface glycoprotein CD3 epsilon chain (CD3E), resulting in recruitment of Cytoplasmic protein NCK2 (NCK2), involved in T cell activation.	details	Inferred
LIG_SH3_5	CD3E_HUMAN	184	188	Specificity	Altered binding specificity	Phosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred