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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: PFAM:PF00640 (8 hits) x


x  Coloured by: Pathway evidence source
          Curated          inferred


x  Index
ErbB signaling pathwayFocal adhesionInsulin signaling pathway
Neurotrophin signaling pathway


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

ErbB signaling pathway (KEGG - hsa04012)
LIG_PTB_Phospho_1 ERBB3_HUMAN13221328BinaryPhysicochemical compatibilityPhosphorylation of Y1328 in the PTB-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred

Focal adhesion (KEGG - hsa04510)
LIG_PTB_Phospho_1 ITB3_HUMAN779785BinaryPhysicochemical compatibilityPhosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred
LIG_PTB_Phospho_1 ITB4_HUMAN15901596BinaryPhysicochemical compatibilityPhosphorylation of Y1596 in the PTB-binding motif of Integrin beta-4 (ITGB4) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred
LIG_PTB_Phospho_1 ITB3_HUMAN779785BinaryPhysicochemical compatibilityPhosphorylation of T779 in the PTB-binding motif of Integrin beta-3 (ITGB3) inhibits its interaction with SHC-transforming protein 1 (SHC1).
details
Inferred
LIG_PTB_Phospho_1 ITB3_HUMAN779785CumulativeRheostaticWhile phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction.
details
Inferred
LIG_PTB_Phospho_1 ITB3_HUMAN779785SpecificityAltered binding specificityPhosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1).
details
Inferred

Insulin signaling pathway (KEGG - hsa04910)
LIG_PTB_Phospho_1 INSR_HUMAN993999BinaryPhysicochemical compatibilityPhosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred

Neurotrophin signaling pathway (KEGG - hsa04722)
LIG_PTB_Phospho_1 NTRK1_HUMAN490496BinaryPhysicochemical compatibilityPhosphorylation of Y496 in the PTB-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein.
details
Inferred
           
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