switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: PFAM:PF00917 (2 hits) x

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Curated inferred

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Motif

Protein

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Information

Evidence

Osteoclast differentiation (KEGG - mmu04380)
LIG_TRAF2_3	CYLD_MOUSE	449	453	Binary	Pre‑translational	Alternative splicing removes the TRAF2-binding motif of Ubiquitin carboxyl-terminal hydrolase CYLD (Cyld), abrogating binding to TNF receptor-associated factor 2 (Traf2). Mice expressing solely the alternatively spliced Isoform 3 of Ubiquitin carboxyl-terminal hydrolase CYLD (Cyld) (sCYLD) show an altered B-cell expansion profile and have more stable NF-kB proteins.	details	Inferred
RIG-I-like receptor signaling pathway (KEGG - mmu04622)
LIG_TRAF2_3	CYLD_MOUSE	449	453	Binary	Pre‑translational	Alternative splicing removes the TRAF2-binding motif of Ubiquitin carboxyl-terminal hydrolase CYLD (Cyld), abrogating binding to TNF receptor-associated factor 2 (Traf2). Mice expressing solely the alternatively spliced Isoform 3 of Ubiquitin carboxyl-terminal hydrolase CYLD (Cyld) (sCYLD) show an altered B-cell expansion profile and have more stable NF-kB proteins.	details	Inferred