switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: PFAM:PF02747 (7 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Base excision repair	Cell cycle	DNA replication
Mismatch repair	Nucleotide excision repair	Synthesis of DNA

Motif

Protein

Start

End

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Information

Evidence

Base excision repair (KEGG - ko03410)
LIG_PCNA_PIPBox_1	DPOD3_HUMAN	456	465	Binary	Physicochemical compatibility	Phosphorylation of S458 in the PCNA-binding motif of DNA polymerase delta subunit 3 (POLD3) by cAMP subfamily reduces the affinity of binding to the Proliferating cell nuclear antigen (PCNA) and decreases the processivity of the polymerase complex.	details	Curated
Cell cycle (KEGG - hsa04110)
LIG_PCNA_PIPBox_1	CDN1A_HUMAN	144	153	Binary	Physicochemical compatibility	Phosphorylation of T145 in the PCNA-binding motif of Cyclin-dependent kinase inhibitor 1 (CDKN1A) by RAC-alpha serine/threonine-protein kinase (AKT1) inhibits binding to Proliferating cell nuclear antigen (PCNA). As a result, Cyclin-dependent kinase inhibitor 1 (CDKN1A) no longer inhibits Proliferating cell nuclear antigen (PCNA) and blocking of DNA replication is relieved.	details	Curated
LIG_PCNA_PIPBox_1	CDN1A_HUMAN	144	153	Binary	Physicochemical compatibility	Phosphorylation of S146 in the PCNA-binding motif of Cyclin-dependent kinase inhibitor 1 (CDKN1A) by PKC subfamily inhibits binding to Proliferating cell nuclear antigen (PCNA). As a result, Cyclin-dependent kinase inhibitor 1 (CDKN1A) no longer inhibits Proliferating cell nuclear antigen (PCNA) and blocking of DNA replication is relieved.	details	Curated
DNA replication (KEGG - ko03030)
LIG_PCNA_PIPBox_1	DPOD3_HUMAN	456	465	Binary	Physicochemical compatibility	Phosphorylation of S458 in the PCNA-binding motif of DNA polymerase delta subunit 3 (POLD3) by cAMP subfamily reduces the affinity of binding to the Proliferating cell nuclear antigen (PCNA) and decreases the processivity of the polymerase complex.	details	Curated
Mismatch repair (KEGG - ko03430)
LIG_PCNA_PIPBox_1	DPOD3_HUMAN	456	465	Binary	Physicochemical compatibility	Phosphorylation of S458 in the PCNA-binding motif of DNA polymerase delta subunit 3 (POLD3) by cAMP subfamily reduces the affinity of binding to the Proliferating cell nuclear antigen (PCNA) and decreases the processivity of the polymerase complex.	details	Curated
Nucleotide excision repair (KEGG - ko03420)
LIG_PCNA_PIPBox_1	DPOD3_HUMAN	456	465	Binary	Physicochemical compatibility	Phosphorylation of S458 in the PCNA-binding motif of DNA polymerase delta subunit 3 (POLD3) by cAMP subfamily reduces the affinity of binding to the Proliferating cell nuclear antigen (PCNA) and decreases the processivity of the polymerase complex.	details	Curated
Synthesis of DNA (Reactome - 69239)
LIG_PCNA_PIPBox_1	DPOD3_HUMAN	456	465	Binary	Physicochemical compatibility	Phosphorylation of S458 in the PCNA-binding motif of DNA polymerase delta subunit 3 (POLD3) by cAMP subfamily reduces the affinity of binding to the Proliferating cell nuclear antigen (PCNA) and decreases the processivity of the polymerase complex.	details	Curated