switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:O43561 (5 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

DAP12 interactions	NF-kappa B signaling pathway	Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway	TCR signaling

Motif

Protein

Start

End

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Information

Evidence

DAP12 interactions (Reactome - 2172127)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated
NF-kappa B signaling pathway (KEGG - hsa04064)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated
Natural killer cell mediated cytotoxicity (KEGG - hsa04650)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated
T cell receptor signaling pathway (KEGG - hsa04660)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated
TCR signaling (Reactome - 202403)
LIG_SH2_STAT5	LAT_HUMAN	161	164	Binary	Physicochemical compatibility	Phosphorylation of Y161 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) protein.	details	Curated