switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:O43639 (3 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Motif

Protein

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Information

Evidence

Axon guidance (KEGG - hsa04360)
LIG_SH2_IA	FAK1_HUMAN	389	405	Binary	Physicochemical compatibility	Phosphorylation of Y397 in the SH2-binding motif of Focal adhesion kinase 1 (PTK2) induces binding to the Cytoplasmic protein NCK2 (NCK2) protein.	details	Inferred
ErbB signaling pathway (KEGG - hsa04012)
LIG_SH2_IA	FAK1_HUMAN	389	405	Binary	Physicochemical compatibility	Phosphorylation of Y397 in the SH2-binding motif of Focal adhesion kinase 1 (PTK2) induces binding to the Cytoplasmic protein NCK2 (NCK2) protein.	details	Inferred
T cell receptor signaling pathway (KEGG - hsa04660)
LIG_SH3_5	CD3E_HUMAN	184	188	Binary	Allostery	Ligand binding to the T cell receptor complex TCR-CD3 results in a conformational change that exposes an SH3-binding motif in T-cell surface glycoprotein CD3 epsilon chain (CD3E), resulting in recruitment of Cytoplasmic protein NCK2 (NCK2), involved in T cell activation.	details	Inferred