switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P31946 (4 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Cell cycle

PI3K-Akt signaling pathway

Motif

Protein

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Information

Evidence

(Reactome - 2721265)
LIG_14-3-3_1	BAD_RAT	134	139	Binary	Physicochemical compatibility	Phosphorylation of S137 by RAC-alpha serine/threonine-protein kinase (Akt1) in the 14-3-3-binding motif of Bcl2 antagonist of cell death (Bad) induces binding to the 14-3-3 protein beta/alpha (YWHAB) protein. This interaction inhibits the pro-apoptotic activity of Bcl2 antagonist of cell death (Bad).	details	Curated
Cell cycle (KEGG - hsa04110)
LIG_14-3-3_3	MPIP3_HUMAN	213	218	Binary	Physicochemical compatibility	Phosphorylation of S216 in a 14-3-3-binding motif of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase Chk1 (CHEK1) induces binding to 14-3-3 protein beta/alpha (YWHAB), which negatively regulates M-phase inducer phosphatase 3 (CDC25C).	details	Curated
LIG_14-3-3_3	MPIP2_HUMAN	320	325	Binary	Physicochemical compatibility	Phosphorylation of S321 in the 14-3-3-binding motif of M-phase inducer phosphatase 2 (CDC25B) by Cyclin-dependent kinase 1 (CDK1) during mitosis abolishes binding of the motif, phosphorylated at S323, to 14-3-3 protein beta/alpha (YWHAB), thereby maintaining active Cdc25B.	details	Curated
PI3K-Akt signaling pathway (KEGG - rno04151)
LIG_14-3-3_1	BAD_RAT	134	139	Binary	Physicochemical compatibility	Phosphorylation of S137 by RAC-alpha serine/threonine-protein kinase (Akt1) in the 14-3-3-binding motif of Bcl2 antagonist of cell death (Bad) induces binding to the 14-3-3 protein beta/alpha (YWHAB) protein. This interaction inhibits the pro-apoptotic activity of Bcl2 antagonist of cell death (Bad).	details	Curated