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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: UNIPROT:P43403 (18 hits) x


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          Curated          inferred


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T cell receptor signaling pathwayTCR signaling


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

T cell receptor signaling pathway (KEGG - hsa04660)
LIG_TYR_ITAM CD3E_HUMAN185202SpecificityAltered binding specificityPhosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Inferred
LIG_TYR_ITAM CD3Z_HUMAN6986Avidity‑sensingPhosphorylation of Y72 and Y83 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_TYR_ITAM CD3Z_HUMAN6986Avidity‑sensingPhosphorylation of Y72 and Y83 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_TYR_ITAM CD3Z_HUMAN108126Avidity‑sensingPhosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_TYR_ITAM CD3Z_HUMAN108126Avidity‑sensingPhosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_TYR_ITAM CD3Z_HUMAN139156Avidity‑sensingPhosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_TYR_ITAM CD3Z_HUMAN139156Avidity‑sensingPhosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_TYR_ITAM CD3G_HUMAN157174Avidity‑sensingPhosphorylation of Y160 and Y171 in the ITAM motif of T-cell surface glycoprotein CD3 gamma chain (CD3G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_TYR_ITAM CD3G_HUMAN157174Avidity‑sensingPhosphorylation of Y160 and Y171 in the ITAM motif of T-cell surface glycoprotein CD3 gamma chain (CD3G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_SH2_IIC ZAP70_HUMAN284300BinaryPhysicochemical compatibilityPhosphorylation of Y292 in the SH2-binding motif of Tyrosine-protein kinase ZAP-70 (ZAP70) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.
details
Inferred

TCR signaling (Reactome - 202403)
LIG_TYR_ITAM CD3Z_HUMAN6986Avidity‑sensingPhosphorylation of Y72 and Y83 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_TYR_ITAM CD3Z_HUMAN6986Avidity‑sensingPhosphorylation of Y72 and Y83 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_TYR_ITAM CD3Z_HUMAN108126Avidity‑sensingPhosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_TYR_ITAM CD3Z_HUMAN108126Avidity‑sensingPhosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_TYR_ITAM CD3Z_HUMAN139156Avidity‑sensingPhosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_TYR_ITAM CD3Z_HUMAN139156Avidity‑sensingPhosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_TYR_ITAM CD3G_HUMAN157174Avidity‑sensingPhosphorylation of Y160 and Y171 in the ITAM motif of T-cell surface glycoprotein CD3 gamma chain (CD3G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
LIG_TYR_ITAM CD3G_HUMAN157174Avidity‑sensingPhosphorylation of Y160 and Y171 in the ITAM motif of T-cell surface glycoprotein CD3 gamma chain (CD3G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Curated
           
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