switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P43405 (10 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Fc epsilon RI signaling pathway	Fc gamma R-mediated phagocytosis	Natural killer cell mediated cytotoxicity
Osteoclast differentiation

Motif

Protein

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End

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Information

Evidence

Fc epsilon RI signaling pathway (KEGG - hsa04664)
LIG_TYR_ITAM	FCERG_HUMAN	62	79	Avidity‑sensing		Phosphorylation of Y65 and Y76 in the ITAM motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).	details	Curated
LIG_TYR_ITAM	FCERG_HUMAN	62	79	Avidity‑sensing		Phosphorylation of Y65 and Y76 in the ITAM motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).	details	Curated
LIG_SH2_IA	FCERG_HUMAN	75	79	Binary	Physicochemical compatibility	Phosphorylation of Y76 in the SH2-binding motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces binding to the Tyrosine-protein kinase SYK (SYK) protein.	details	Curated
Fc gamma R-mediated phagocytosis (KEGG - hsa04666)
LIG_TYR_ITAM	FCG2A_HUMAN	285	307	Avidity‑sensing		Phosphorylation of Y288 and Y304 in the ITAM motif of Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).	details	Curated
LIG_TYR_ITAM	FCG2A_HUMAN	285	307	Avidity‑sensing		Phosphorylation of Y288 and Y304 in the ITAM motif of Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).	details	Curated
Natural killer cell mediated cytotoxicity (KEGG - hsa04650)
LIG_TYR_ITAM	FCERG_HUMAN	62	79	Avidity‑sensing		Phosphorylation of Y65 and Y76 in the ITAM motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).	details	Curated
LIG_TYR_ITAM	FCERG_HUMAN	62	79	Avidity‑sensing		Phosphorylation of Y65 and Y76 in the ITAM motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).	details	Curated
LIG_SH2_IA	FCERG_HUMAN	75	79	Binary	Physicochemical compatibility	Phosphorylation of Y76 in the SH2-binding motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces binding to the Tyrosine-protein kinase SYK (SYK) protein.	details	Curated
Osteoclast differentiation (KEGG - hsa04380)
LIG_TYR_ITAM	FCG2A_HUMAN	285	307	Avidity‑sensing		Phosphorylation of Y288 and Y304 in the ITAM motif of Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).	details	Curated
LIG_TYR_ITAM	FCG2A_HUMAN	285	307	Avidity‑sensing		Phosphorylation of Y288 and Y304 in the ITAM motif of Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).	details	Curated