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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: UNIPROT:P98170 (1 hits) x


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Apoptosis


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Apoptosis (KEGG - hsa04210)
LIG_BIR_III_2 CASP9_HUMAN315319BinaryPhysicochemical compatibilityBinding of the BIR domain-binding motif of Caspase-9 (CASP9) to the BIR domains of Baculoviral IAP repeat-containing protein 4 (XIAP) requires cleavage of Caspase-9 (CASP9) at D315, since this results in a functional neo N-terminal motif. BIR domains are found in Inhibitor of Apoptosis Proteins (IAPs) that suppress the activity of activated caspases, either by directly inhibiting caspase catalytic activity, or by targeting caspases for degradation by ubiquitin modification.
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Inferred
           
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