switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:Q96CW1 (3 hits) x

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Curated inferred

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Evidence

Endocytosis (KEGG - hsa04144)
TRG_ENDOCYTIC_2	EGFR_HUMAN	998	1001	Binary	Allostery	Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Epidermal growth factor receptor (EGFR) via an endocytosis motif.	details	Inferred
TRG_ENDOCYTIC_2	TFR1_HUMAN	20	23	Binary	Allostery	Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Transferrin receptor protein 1 (TFRC) via an endocytosis motif.	details	Inferred
TRG_ENDOCYTIC_2	PI51C_HUMAN	649	652	Binary	Physicochemical compatibility	Phosphorylation of S645 near the AP2-binding motif of Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) by Cyclin-dependent kinase 5 (Cdk5) inhibits its interaction with AP-2 complex subunit mu (AP2M1).	details	Inferred