switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Group Index Colouring Info Filtered: ELM:DEG_SCF_TRCP1_1 (18 hits) x

x Coloured by switch type.

Domain hiding	Altered binding specificity	Motif hiding	Composite binding site formation
Uncategorised	Rheostatic	Allostery	Avidity-sensing
Physicochemical compatibility	Pre-translational	Competition

x Index

Catenin beta-1	Claspin	Cyclic AMP-dependent transcription factor ATF-4
Disks large homolog 1	F-box only protein 5	FYVE, RhoGEF and PH domain-containing protein 1
FYVE, RhoGEF and PH domain-containing protein 3	Latent membrane protein 1 (Epstein-Barr)	NF-kappa-B inhibitor alpha
NF-kappa-B inhibitor beta	NF-kappa-B inhibitor epsilon	Nuclear factor NF-kappa-B p105 subunit
Programmed cell death protein 4	Prolactin receptor	Protein Vpu (Human)
Protein aurora borealis	Zinc finger protein SNAI1

Motif

Start

End

Switch Type

Switch Subtype

Switch Description

Information

Catenin beta-1 - CTNNB1 - Homo sapiens
DEG_SCF_TRCP1_1	32	37	Specificity	Altered binding specificity	Phosphorylation of Catenin beta-1 (CTNNB1) at T41 generates a docking site for Glycogen synthase kinase-3 beta (GSK3B), which then phosphorylates S37, thereby generating a new docking site for GSK3B. Subsequent phosphorylation of S33 by GSK3B switches the specificity of CTNNB1 to the F-box/WD repeat-containing protein 1A (BTRC), which recruits CTNNB1 to the SCF ubiquitin ligase complex.	details
Claspin - CLSPN - Homo sapiens
DEG_SCF_TRCP1_1	29	34	Binary	Physicochemical compatibility	Dual phosphorylation of S30 and S34 in the TrCP1-binding motif of Claspin (CLSPN) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
Cyclic AMP-dependent transcription factor ATF-4 - ATF4 - Homo sapiens
DEG_SCF_TRCP1_1	218	224	Binary	Physicochemical compatibility	Dual phosphorylation of S219 and S224 in the TrCP1-binding motif of Cyclic AMP-dependent transcription factor ATF-4 (ATF4) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
Disks large homolog 1 - DLG1 - Homo sapiens
DEG_SCF_TRCP1_1	597	602	Binary	Physicochemical compatibility	Dual phosphorylation of S598 and S602 in the TrCP1-binding motif of Disks large homolog 1 (DLG1) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
F-box only protein 5 - FBXO5 - Homo sapiens
DEG_SCF_TRCP1_1	144	149	Binary	Physicochemical compatibility	Dual phosphorylation of S145 and S149 in the TrCP1-binding motif of F-box only protein 5 (FBXO5) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
FYVE, RhoGEF and PH domain-containing protein 1 - FGD1 - Homo sapiens
DEG_SCF_TRCP1_1	282	287	Specificity	Altered binding specificity	Phosphorylation of FYVE, RhoGEF and PH domain-containing protein 1 (FGD1), a GEF for CDC42 small effector protein 2 (CDC42SE2), by Glycogen synthase kinase-3 beta (GSK3B) targets FGD1 to the SCF ubiquitin ligase complex, F-box/WD repeat-containing protein 1A (BTRC), which marks FGD1 for degradation.	details
FYVE, RhoGEF and PH domain-containing protein 3 - FGD3 - Homo sapiens
DEG_SCF_TRCP1_1	75	80	Specificity	Altered binding specificity	Phosphorylation of FYVE, RhoGEF and PH domain-containing protein 3 (FGD3), a GEF for CDC42 small effector protein 2 (CDC42SE2), by Glycogen synthase kinase-3 beta (GSK3B) targets FGD3 to the SCF ubiquitin ligase complex, F-box/WD repeat-containing protein 1A (BTRC), which marks FGD3 for degradation.	details
Latent membrane protein 1 - LMP1 - Epstein-Barr virus (strain B95-8)
DEG_SCF_TRCP1_1	210	215	Binary	Physicochemical compatibility	Dual phosphorylation of S211 and S215 in the TrCP1-binding motif of Latent membrane protein 1 (LMP1) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
NF-kappa-B inhibitor alpha - NFKBIA - Homo sapiens
DEG_SCF_TRCP1_1	31	36	Binary	Physicochemical compatibility	Dual phosphorylation of S32 and S36 in the TrCP1-binding motif of NF-kappa-B inhibitor alpha (NFKBIA) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
NF-kappa-B inhibitor beta - NFKBIB - Homo sapiens
DEG_SCF_TRCP1_1	18	23	Binary	Physicochemical compatibility	Dual phosphorylation of S19 and S23 in the TrCP1-binding motif of NF-kappa-B inhibitor beta (NFKBIB) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
NF-kappa-B inhibitor epsilon - NFKBIE - Homo sapiens
DEG_SCF_TRCP1_1	156	161	Binary	Physicochemical compatibility	Dual phosphorylation of S157 and S161 in the TrCP1-binding motif of NF-kappa-B inhibitor epsilon (NFKBIE) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
Nuclear factor NF-kappa-B p105 subunit - NFKB1 - Homo sapiens
DEG_SCF_TRCP1_1	926	932	Binary	Physicochemical compatibility	Dual phosphorylation of S927 and S932 in the TrCP1-binding motif of Nuclear factor NF-kappa-B p105 subunit (NFKB1) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
Programmed cell death protein 4 - PDCD4 - Homo sapiens
DEG_SCF_TRCP1_1	70	76	Binary	Physicochemical compatibility	Dual phosphorylation of S71 and S76 in the TrCP1-binding motif of Programmed cell death protein 4 (PDCD4) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
Prolactin receptor - PRLR - Homo sapiens
DEG_SCF_TRCP1_1	348	353	Binary	Physicochemical compatibility	Dual phosphorylation of S349 and S353 in the TrCP1-binding motif of Prolactin receptor (PRLR) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
DEG_SCF_TRCP1_1	348	353	Binary	Pre‑translational	Alternative Splicing removes the degron motif of Prolactin receptor (PRLR) abrogating binding to F-box/WD repeat-containing protein 11 (FBXW11). SCF-beta-TrCP2 negatively regulates the long isoform of PRLR (Isoform 1 of Prolactin receptor (PRLR)). Should be noted that TrCP2 has a predominately cytoplasmic localisation compared to TrCP1 that is located in the nucleus. The mechanism for the down-regulation of the intermediate (Isoform Intermediate of Prolactin receptor (PRLR)) and short (Isoform Short form 1a of Prolactin receptor (PRLR) and Isoform Short form 1b of Prolactin receptor (PRLR)) that lack the TrCP degron is still not known. However it should be noted that the short and intermediate are either partially deficient or entirely deficient in mediating the signal transduction pathways induced by PRL (see Kine et al. (1999) (here) and Ross et al. (1997) (here)). This though is likely due to the missing STAT5-SH2-binding motif.	details
Protein Vpu - vpu - Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)
DEG_SCF_TRCP1_1	51	56	Binary	Physicochemical compatibility	Dual phosphorylation of S52 and S56 in the TrCP1-binding motif of Protein Vpu (vpu) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
Protein aurora borealis - BORA - Homo sapiens
DEG_SCF_TRCP1_1	496	501	Binary	Physicochemical compatibility	Dual phosphorylation of S497 and T501 in the TrCP1-binding motif of Protein aurora borealis (BORA) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details
Zinc finger protein SNAI1 - SNAI1 - Homo sapiens
DEG_SCF_TRCP1_1	95	100	Specificity	Altered binding specificity	Phosphorylation of Zinc finger protein SNAI1 (SNAI1) at S100 generates a docking site for Glycogen synthase kinase-3 beta (GSK3B). Subsequent phosphorylation of S96 by GSK3B targets Zinc finger protein SNAI1 (SNAI1) to the SCF ubiquitin ligase complexes F-box/WD repeat-containing protein 1A (BTRC), which marks it for degradation.	details