switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Group Index Colouring Info Filtered: ELM:LIG_SH2_III (16 hits) x

x Coloured by switch type.

Domain hiding	Altered binding specificity	Motif hiding	Composite binding site formation
Uncategorised	Rheostatic	Allostery	Avidity-sensing
Physicochemical compatibility	Pre-translational	Competition

x Index

Epidermal growth factor receptor	Erythropoietin receptor	Growth hormone receptor
Interferon gamma receptor 1	Interleukin-2 receptor subunit beta	Interleukin-4 receptor subunit alpha
Leptin receptor (Mus)	Receptor tyrosine-protein kinase erbB-2	Receptor tyrosine-protein kinase erbB-3
Signal transducer and activator of transcription 5A	Tyrosine-protein kinase JAK2 (Mus)

Motif

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Information

Epidermal growth factor receptor - EGFR - Homo sapiens
LIG_SH2_III	1008	1024	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Signal transducer and activator of transcription 6 (STAT6) protein.	details
Erythropoietin receptor - EPOR - Homo sapiens
LIG_SH2_III	360	376	Binary	Physicochemical compatibility	Phosphorylation of Y368 in the SH2-binding motif of Erythropoietin receptor (EPOR) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details
LIG_SH2_III	418	434	Binary	Physicochemical compatibility	Phosphorylation of Y426 in the SH2-binding motif of Erythropoietin receptor (EPOR) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details
LIG_SH2_III	496	508	Binary	Physicochemical compatibility	Phosphorylation of Y504 in the SH2-binding motif of Erythropoietin receptor (EPOR) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details
Growth hormone receptor - GHR - Homo sapiens
LIG_SH2_III	428	444	Binary	Physicochemical compatibility	Phosphorylation of Y436 in the SH2-binding motif of Growth hormone receptor (GHR) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details
Interferon gamma receptor 1 - IFNGR1 - Homo sapiens
LIG_SH2_III	457	461	Binary	Physicochemical compatibility	Phosphorylation of Y457 in the SH2-binding motif of Interferon gamma receptor 1 (IFNGR1) induces binding to the Signal transducer and activator of transcription 1-alpha/beta (STAT1) protein.	details
Interleukin-2 receptor subunit beta - IL2RB - Homo sapiens
LIG_SH2_III	531	540	Binary	Physicochemical compatibility	Phosphorylation of Y536 in the SH2-binding motif of Interleukin-2 receptor subunit beta (IL2RB) induces binding to the Signal transducer and activator of transcription 5A (STAT5A) protein.	details
LIG_SH2_III	528	544	Binary	Physicochemical compatibility	Phosphorylation of Y536 in the SH2-binding motif of Interleukin-2 receptor subunit beta (IL2RB) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details
Interleukin-4 receptor subunit alpha - IL4R - Homo sapiens
LIG_SH2_III	566	585	Binary	Physicochemical compatibility	Phosphorylation of Y575 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Signal transducer and activator of transcription 6 (STAT6) protein.	details
LIG_SH2_III	594	613	Binary	Physicochemical compatibility	Phosphorylation of Y603 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Signal transducer and activator of transcription 6 (STAT6) protein.	details
LIG_SH2_III	622	641	Binary	Physicochemical compatibility	Phosphorylation of Y631 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Signal transducer and activator of transcription 6 (STAT6) protein.	details
Leptin receptor - Lepr - Mus musculus
LIG_SH2_III	1129	1148	Binary	Physicochemical compatibility	Phosphorylation of Y1138 in the SH2-binding motif of Leptin receptor (Lepr) induces binding to the Signal transducer and activator of transcription 3 (STAT3) protein.	details
Receptor tyrosine-protein kinase erbB-2 - ERBB2 - Homo sapiens
LIG_SH2_III	1131	1147	Binary	Physicochemical compatibility	Phosphorylation of Y1139 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-2 (ERBB2) induces binding to the Signal transducer and activator of transcription 6 (STAT6) protein.	details
Receptor tyrosine-protein kinase erbB-3 - ERBB3 - Homo sapiens
LIG_SH2_III	1320	1336	Binary	Physicochemical compatibility	Phosphorylation of Y1328 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to the Signal transducer and activator of transcription 6 (STAT6) protein.	details
Signal transducer and activator of transcription 5A - STAT5A - Homo sapiens
LIG_SH2_III	686	702	Binary	Physicochemical compatibility	Phosphorylation of Y694 in the SH2-binding motif of Signal transducer and activator of transcription 5A (STAT5A) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details
Tyrosine-protein kinase JAK2 - Jak2 - Mus musculus
LIG_SH2_III	804	820	Binary	Physicochemical compatibility	Phosphorylation of Y813 in the SH2-binding motif of Tyrosine-protein kinase JAK2 (Jak2) induces binding to the Signal transducer and activator of transcription 5B (Stat5b) protein.	details