switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Group Index Colouring Info Filtered: ELM:LIG_TYR_ITAM (17 hits) x

x Coloured by switch type.

Domain hiding	Altered binding specificity	Motif hiding	Composite binding site formation
Uncategorised	Rheostatic	Allostery	Avidity-sensing
Physicochemical compatibility	Pre-translational	Competition

x Index

B-cell antigen receptor complex-associated protein alpha chain (Mus)	High affinity immunoglobulin epsilon receptor subunit gamma	Low affinity immunoglobulin gamma Fc region receptor II-a
T-cell surface glycoprotein CD3 epsilon chain	T-cell surface glycoprotein CD3 gamma chain	T-cell surface glycoprotein CD3 zeta chain

Motif

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Information

B-cell antigen receptor complex-associated protein alpha chain - Cd79a - Mus musculus
LIG_TYR_ITAM	179	196	Avidity‑sensing		Phosphorylation of Y182 and Y193 in the ITAM motif of B-cell antigen receptor complex-associated protein alpha chain (Cd79a) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (Syk). Maximal Syk activation requires both Syk SH2 domains and phosphorylation of both ITAM tyrosine residues.	details
LIG_TYR_ITAM	179	196	Avidity‑sensing		Phosphorylation of Y182 and Y193 in the ITAM motif of B-cell antigen receptor complex-associated protein alpha chain (Cd79a) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (Syk). Maximal Syk activation requires both Syk SH2 domains and phosphorylation of both ITAM tyrosine residues.	details
High affinity immunoglobulin epsilon receptor subunit gamma - FCER1G - Homo sapiens
LIG_TYR_ITAM	62	79	Avidity‑sensing		Phosphorylation of Y65 and Y76 in the ITAM motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).	details
LIG_TYR_ITAM	62	79	Avidity‑sensing		Phosphorylation of Y65 and Y76 in the ITAM motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).	details
Low affinity immunoglobulin gamma Fc region receptor II-a - FCGR2A - Homo sapiens
LIG_TYR_ITAM	285	307	Avidity‑sensing		Phosphorylation of Y288 and Y304 in the ITAM motif of Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).	details
LIG_TYR_ITAM	285	307	Avidity‑sensing		Phosphorylation of Y288 and Y304 in the ITAM motif of Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).	details
T-cell surface glycoprotein CD3 epsilon chain - CD3E - Homo sapiens
LIG_TYR_ITAM	185	202	Specificity	Altered binding specificity	Phosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70).	details
LIG_TYR_ITAM	185	202	Avidity‑sensing		Phosphorylation of Y188 and Y199 in the ITAM motif of T-cell surface glycoprotein CD3 epsilon chain (CD3E) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).	details
LIG_TYR_ITAM	185	202	Avidity‑sensing		Phosphorylation of Y188 and Y199 in the ITAM motif of T-cell surface glycoprotein CD3 epsilon chain (CD3E) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).	details
T-cell surface glycoprotein CD3 gamma chain - CD3G - Homo sapiens
LIG_TYR_ITAM	157	174	Avidity‑sensing		Phosphorylation of Y160 and Y171 in the ITAM motif of T-cell surface glycoprotein CD3 gamma chain (CD3G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details
LIG_TYR_ITAM	157	174	Avidity‑sensing		Phosphorylation of Y160 and Y171 in the ITAM motif of T-cell surface glycoprotein CD3 gamma chain (CD3G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details
T-cell surface glycoprotein CD3 zeta chain - CD247 - Homo sapiens
LIG_TYR_ITAM	69	86	Avidity‑sensing		Phosphorylation of Y72 and Y83 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details
LIG_TYR_ITAM	69	86	Avidity‑sensing		Phosphorylation of Y72 and Y83 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details
LIG_TYR_ITAM	108	126	Avidity‑sensing		Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details
LIG_TYR_ITAM	108	126	Avidity‑sensing		Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details
LIG_TYR_ITAM	139	156	Avidity‑sensing		Phosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details
LIG_TYR_ITAM	139	156	Avidity‑sensing		Phosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).	details