About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: PFAM:PF00134 (6 hits) x
submit


x  Coloured by switch type.
  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
A-kinase anchor protein 12 (Mus)Cell division control protein 6 homologCyclin-dependent kinase inhibitor 1
Cyclin-dependent kinase inhibitor 1BM-phase inducer phosphatase 1Retinoblastoma-associated protein


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

A-kinase anchor protein 12 - Akap12 -  Mus musculus
DOC_CYCLIN_1501504BinaryPhysicochemical compatibilityPhosphorylation of S507 adjacent to the cyclin-binding motif of A-kinase anchor protein 12 (Akap12) by PKC subfamily blocks binding to the G1/S-specific cyclin-D1 (Ccnd1). As a result, the function of A-kinase anchor protein 12 (Akap12) as a scaffold is inhibited and G1/S-specific cyclin-D1 (Ccnd1) is translocated to the nucleus where it regulates progression of the cell cycle from G1 to S phase.
details

Cell division control protein 6 homolog - CDC6 -  Homo sapiens
DOC_CYCLIN_19498SpecificityDomain hidingBinding of the CDK-cyclin inhibitor p27 (Cyclin-dependent kinase inhibitor 1B (CDKN1B)) blocks the substrate recruitment site on Cyclin-A2 (CCNA2).
details

Cyclin-dependent kinase inhibitor 1 - CDKN1A -  Homo sapiens
DOC_CYCLIN_11922SpecificityCompetitionCyclin-dependent kinase inhibitor 1 (CDKN1A) (p21) and the M-phase inducer phosphatase 1 (CDC25A) bind the same site on Cyclin proteins (e.g. G1/S-specific cyclin-E1 (CCNE1)), making their interactions mutually exclusive.
details

Cyclin-dependent kinase inhibitor 1B - CDKN1B -  Homo sapiens
DOC_CYCLIN_13033SpecificityDomain hidingBinding of the CDK-cyclin inhibitor p27 (Cyclin-dependent kinase inhibitor 1B (CDKN1B)) blocks the substrate recruitment site on Cyclin-A2 (CCNA2).
details

M-phase inducer phosphatase 1 - CDC25A -  Homo sapiens
DOC_CYCLIN_11115SpecificityCompetitionCyclin-dependent kinase inhibitor 1 (CDKN1A) (p21) and the M-phase inducer phosphatase 1 (CDC25A) bind the same site on Cyclin proteins (e.g. G1/S-specific cyclin-E1 (CCNE1)), making their interactions mutually exclusive.
details

Retinoblastoma-associated protein - RB1 -  Homo sapiens
DOC_CYCLIN_1873877SpecificityCompetitionThe docking sites for PP1 (e.g. Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)) and Cdk-Cyclins (e.g. Cyclin-A2 (CCNA2)) on Retinoblastoma-associated protein (RB1) overlap, which makes their binding to RB1 mutually exclusive. Hypophosphorylated RB1 blocks E2F-dependent transcription, while hyperphosphorylation inactivates RB1 as a repressor, thereby promoting cell cycle progression.
details
           
Please send any suggestions/comments to: switches@elm.eu.org