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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: PFAM:PF00400 (43 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
APC/C-CDH1 modulator 1 (Saccharomyces)Bcl-2-like protein 11Catenin beta-1
ClaspinCyclic AMP-dependent transcription factor ATF-4Disks large homolog 1
F-box only protein 5FYVE, RhoGEF and PH domain-containing protein 1FYVE, RhoGEF and PH domain-containing protein 3
G1/S-specific cyclin-E1G1/S-specific cyclin-E1G2/mitotic-specific cyclin-2 (Saccharomyces)
G2/mitotic-specific cyclin-B1Homeobox protein goosecoidKinesin-like protein CIN8 (Saccharomyces)
Large T antigen (Simian)Latent membrane protein 1 (Epstein-Barr)M-phase inducer phosphatase 2
Mitotic checkpoint serine/threonine-protein kinase BUB1 betaMyc proto-oncogene proteinNF-kappa-B inhibitor alpha
NF-kappa-B inhibitor betaNF-kappa-B inhibitor epsilonNeurogenic locus notch homolog protein 1
Nuclear factor NF-kappa-B p105 subunitProbable serine/threonine-protein kinase HSL1 (Saccharomyces)Programmed cell death protein 4
Prolactin receptorProtein Vpu (Human)Protein aurora borealis
RE1-silencing transcription factorSecurinSerine/threonine-protein kinase Nek2
Sterol regulatory element-binding protein 1Transcription factor AP-1Transcription factor HES-1
UDP-galactose translocatorYorkie homologZinc finger protein SNAI1


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

APC/C-CDH1 modulator 1 - ACM1 -  Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
DEG_APCC_KENBOX_297101SpecificityDomain hidingThe KEN-box motif of APC/C-CDH1 modulator 1 (ACM1) binds to the substrate recruitment site of APC/C activator protein CDH1 (CDH1), the substrate recognition subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), and thereby blocks recruitment, and subsequent targeting for proteasomal degradation, of the Cdh1 substrate G2/mitotic-specific cyclin-2 (CLB2). Degradation of G2/mitotic-specific cyclin-2 (CLB2) is required for mitotic exit and maintenance of the G1 phase of the cell cycle and is allowed by Cdc20-dependent degradation of APC/C-CDH1 modulator 1 (ACM1) in anaphase.
details
DEG_APCC_KENBOX_297101SpecificityDomain hidingThe KEN-box motif of APC/C-CDH1 modulator 1 (ACM1) binds to the substrate recruitment site of APC/C activator protein CDH1 (CDH1), the substrate recognition subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), and thereby blocks recruitment, and subsequent targeting for proteasomal degradation, of the Cdh1 substrate Kinesin-like protein CIN8 (CIN8). Degradation of Kinesin-like protein CIN8 (CIN8) is required for mitotic exit and maintenance of the G1 phase of the cell cycle and is allowed by Cdc20-dependent degradation of APC/C-CDH1 modulator 1 (ACM1) in anaphase.
details
DEG_APCC_KENBOX_297101SpecificityDomain hidingThe KEN-box motif of APC/C-CDH1 modulator 1 (ACM1) binds to the substrate recruitment site of APC/C activator protein CDH1 (CDH1), the substrate recognition subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), and thereby blocks recruitment, and subsequent targeting for proteasomal degradation, of the Cdh1 substrate Probable serine/threonine-protein kinase HSL1 (HSL1). Degradation of Probable serine/threonine-protein kinase HSL1 (HSL1) is required for mitotic exit and maintenance of the G1 phase of the cell cycle and is allowed by Cdc20-dependent degradation of APC/C-CDH1 modulator 1 (ACM1) in anaphase.
details

Bcl-2-like protein 11 - BCL2L11 -  Homo sapiens
DEG_SCF_TRCP1_29398BinaryPre‑translationalAlternative splicing removes the extended SCF-TrCP degron motif of Bcl-2-like protein 11 (BCL2L11), abrogating binding to F-box/WD repeat-containing protein 1A (BTRC). Upon mitogen survival signals, RPS6KA1 and RPS6KA2 kinases are up-regulated and rapidly phosphorylate the three serines of Isoform Bim(EL) of Bcl-2-like protein 11 (BCL2L11). This facilitates the binding of betaTrCP and subsequent ubiquitination and degradation of Isoform Bim(EL) of Bcl-2-like protein 11 (BCL2L11).
details

Catenin beta-1 - CTNNB1 -  Homo sapiens
DEG_SCF_TRCP1_13237SpecificityAltered binding specificityPhosphorylation of Catenin beta-1 (CTNNB1) at T41 generates a docking site for Glycogen synthase kinase-3 beta (GSK3B), which then phosphorylates S37, thereby generating a new docking site for GSK3B. Subsequent phosphorylation of S33 by GSK3B switches the specificity of CTNNB1 to the F-box/WD repeat-containing protein 1A (BTRC), which recruits CTNNB1 to the SCF ubiquitin ligase complex.
details

Claspin - CLSPN -  Homo sapiens
DEG_SCF_TRCP1_12934BinaryPhysicochemical compatibilityDual phosphorylation of S30 and S34 in the TrCP1-binding motif of Claspin (CLSPN) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
details

Cyclic AMP-dependent transcription factor ATF-4 - ATF4 -  Homo sapiens
DEG_SCF_TRCP1_1218224BinaryPhysicochemical compatibilityDual phosphorylation of S219 and S224 in the TrCP1-binding motif of Cyclic AMP-dependent transcription factor ATF-4 (ATF4) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
details

Disks large homolog 1 - DLG1 -  Homo sapiens
DEG_SCF_TRCP1_1597602BinaryPhysicochemical compatibilityDual phosphorylation of S598 and S602 in the TrCP1-binding motif of Disks large homolog 1 (DLG1) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
details

F-box only protein 5 - FBXO5 -  Homo sapiens
DEG_SCF_TRCP1_1144149BinaryPhysicochemical compatibilityDual phosphorylation of S145 and S149 in the TrCP1-binding motif of F-box only protein 5 (FBXO5) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
details

FYVE, RhoGEF and PH domain-containing protein 1 - FGD1 -  Homo sapiens
DEG_SCF_TRCP1_1282287SpecificityAltered binding specificityPhosphorylation of FYVE, RhoGEF and PH domain-containing protein 1 (FGD1), a GEF for CDC42 small effector protein 2 (CDC42SE2), by Glycogen synthase kinase-3 beta (GSK3B) targets FGD1 to the SCF ubiquitin ligase complex, F-box/WD repeat-containing protein 1A (BTRC), which marks FGD1 for degradation.
details

FYVE, RhoGEF and PH domain-containing protein 3 - FGD3 -  Homo sapiens
DEG_SCF_TRCP1_17580SpecificityAltered binding specificityPhosphorylation of FYVE, RhoGEF and PH domain-containing protein 3 (FGD3), a GEF for CDC42 small effector protein 2 (CDC42SE2), by Glycogen synthase kinase-3 beta (GSK3B) targets FGD3 to the SCF ubiquitin ligase complex, F-box/WD repeat-containing protein 1A (BTRC), which marks FGD3 for degradation.
details

G1/S-specific cyclin-E1 - CCNE1 -  Homo sapiens
DEG_SCF_FBW7_1393399SpecificityAltered binding specificityPhosphorylation of G1/S-specific cyclin-E1 (CCNE1) at S399 generates a docking site for Glycogen synthase kinase-3 beta (GSK3B). Subsequent phosphorylation of CCNE1 by Glycogen synthase kinase-3 beta (GSK3B) at T395 switches the specificity of CCNE1 to the F-box/WD repeat-containing protein 7 (FBXW7), which recruits CCNE1 to the SCF ubiquitin ligase complex to mark CCNE1 for degradation.
details

G1/S-specific cyclin-E1 - CCNE1 -  Homo sapiens
DEG_SCF_FBW7_1378384SpecificityAltered binding specificityPhosphorylation of Isoform E-S of G1/S-specific cyclin-E1 (CCNE1) at S384 by CDK2 primes CCNE1 for phosphorylation by Glycogen synthase kinase-3 beta (GSK3B) at T380, which creates a recognition site for F box proteins of the SCF ubiquitin ligase complex (F-box/WD repeat-containing protein 7 (FBXW7)) that target CCNE1 for degradation.
details

G2/mitotic-specific cyclin-2 - CLB2 -  Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
DEG_APCC_KENBOX_299103SpecificityDomain hidingThe KEN-box motif of APC/C-CDH1 modulator 1 (ACM1) binds to the substrate recruitment site of APC/C activator protein CDH1 (CDH1), the substrate recognition subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), and thereby blocks recruitment, and subsequent targeting for proteasomal degradation, of the Cdh1 substrate G2/mitotic-specific cyclin-2 (CLB2). Degradation of G2/mitotic-specific cyclin-2 (CLB2) is required for mitotic exit and maintenance of the G1 phase of the cell cycle and is allowed by Cdc20-dependent degradation of APC/C-CDH1 modulator 1 (ACM1) in anaphase.
details

G2/mitotic-specific cyclin-B1 - CCNB1 -  Homo sapiens
DEG_APCC_DBOX_14149SpecificityDomain hidingBinding of the second KEN-box motif of Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B), a subunit of the Spindle Assembly Checkpoint (SAC), to the substrate recruitment site of Cell division cycle protein 20 homolog (CDC20), the substrate recognition subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), blocks binding of the Cdc20 substrate G2/mitotic-specific cyclin-B1 (CCNB1). As a result, G2/mitotic-specific cyclin-B1 (CCNB1) is not targeted for proteasomal degradation until metaphase, when the SAC is inhibited. Destruction of G2/mitotic-specific cyclin-B1 (CCNB1) is required for progression to the anaphase of the cell cycle.
details

Homeobox protein goosecoid - GSC -  Homo sapiens
LIG_EH1_1513SpecificityCompetitionThe Transducin-like enhancer protein 1 (TLE1) can recruit a wide range of transcriptional repressors via its WD domain, to which the WRPW motif of Transcription factor HES-1 (HES1) and the EH1 motif of Homeobox protein goosecoid (GSC) can bind using overlapping sites.
details

Kinesin-like protein CIN8 - CIN8 -  Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
DEG_APCC_KENBOX_2931935SpecificityDomain hidingThe KEN-box motif of APC/C-CDH1 modulator 1 (ACM1) binds to the substrate recruitment site of APC/C activator protein CDH1 (CDH1), the substrate recognition subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), and thereby blocks recruitment, and subsequent targeting for proteasomal degradation, of the Cdh1 substrate Kinesin-like protein CIN8 (CIN8). Degradation of Kinesin-like protein CIN8 (CIN8) is required for mitotic exit and maintenance of the G1 phase of the cell cycle and is allowed by Cdc20-dependent degradation of APC/C-CDH1 modulator 1 (ACM1) in anaphase.
details

Large T antigen - -  Simian virus 40
DEG_SCF_FBW7_2699705BinaryPhysicochemical compatibilityPhosphorylation of T701 in the degron of Large T antigen induces binding to the F-box/WD repeat-containing protein 7 (FBXW7) protein, which recruits it to the SCF ubiquitin ligase complex where it is marked for degradation.
details

Latent membrane protein 1 - LMP1 -  Epstein-Barr virus (strain B95-8)
DEG_SCF_TRCP1_1210215BinaryPhysicochemical compatibilityDual phosphorylation of S211 and S215 in the TrCP1-binding motif of Latent membrane protein 1 (LMP1) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
details

M-phase inducer phosphatase 2 - CDC25B -  Homo sapiens
DEG_APCC_KENBOX_2191195BinaryPre‑translationalAlternative splicing removes the APC/C KEN-box degron motif of M-phase inducer phosphatase 2 (CDC25B), abrogating binding to Fizzy-related protein homolog (FZR1). The motif-lacking Isoform CDC25B2 of M-phase inducer phosphatase 2 (CDC25B) is not degraded during mitosis, unlike other isoforms.
details

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta - BUB1B -  Homo sapiens
DEG_APCC_KENBOX_2303307SpecificityDomain hidingBinding of the second KEN-box motif of Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B), a subunit of the Spindle Assembly Checkpoint (SAC), to the substrate recruitment site of Cell division cycle protein 20 homolog (CDC20), the substrate recognition subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), blocks binding of the Cdc20 substrate G2/mitotic-specific cyclin-B1 (CCNB1). As a result, G2/mitotic-specific cyclin-B1 (CCNB1) is not targeted for proteasomal degradation until metaphase, when the SAC is inhibited. Destruction of G2/mitotic-specific cyclin-B1 (CCNB1) is required for progression to the anaphase of the cell cycle.
details
DEG_APCC_KENBOX_2303307SpecificityDomain hidingBinding of the second KEN-box motif of Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B), a subunit of the Spindle Assembly Checkpoint (SAC), to the substrate recruitment site of Cell division cycle protein 20 homolog (CDC20), the substrate recognition subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), blocks binding of the Cdc20 substrate Securin (PTTG1). As a result, Securin (PTTG1) is not targeted for proteasomal degradation until metaphase, when the SAC is inhibited. Destruction of Securin (PTTG1) is required for progression to the anaphase of the cell cycle.
details

Myc proto-oncogene protein - MYC -  Homo sapiens
DEG_SCF_FBW7_15562SpecificityAltered binding specificityPhosphorylation of Myc proto-oncogene protein (MYC) at S62 by Mitogen-activated protein kinase 1 (MAPK1) primes MYC for phosphorylation by Glycogen synthase kinase-3 beta (GSK3B), which targets MYC to the SCF ubiquitin ligase complex, F-box/WD repeat-containing protein 7 (FBXW7) that marks MYC for degradation.
details

NF-kappa-B inhibitor alpha - NFKBIA -  Homo sapiens
DEG_SCF_TRCP1_13136BinaryPhysicochemical compatibilityDual phosphorylation of S32 and S36 in the TrCP1-binding motif of NF-kappa-B inhibitor alpha (NFKBIA) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
details

NF-kappa-B inhibitor beta - NFKBIB -  Homo sapiens
DEG_SCF_TRCP1_11823BinaryPhysicochemical compatibilityDual phosphorylation of S19 and S23 in the TrCP1-binding motif of NF-kappa-B inhibitor beta (NFKBIB) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
details

NF-kappa-B inhibitor epsilon - NFKBIE -  Homo sapiens
DEG_SCF_TRCP1_1156161BinaryPhysicochemical compatibilityDual phosphorylation of S157 and S161 in the TrCP1-binding motif of NF-kappa-B inhibitor epsilon (NFKBIE) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
details

Neurogenic locus notch homolog protein 1 - NOTCH1 -  Homo sapiens
DEG_SCF_FBW7_225082515BinaryPhysicochemical compatibilityPhosphorylation of T2511 in the degron of Neurogenic locus notch homolog protein 1 (NOTCH1) induces binding to the F-box/WD repeat-containing protein 7 (FBXW7) protein, which recruits it to the SCF ubiquitin ligase complex where it is marked for degradation.
details

Nuclear factor NF-kappa-B p105 subunit - NFKB1 -  Homo sapiens
DEG_SCF_TRCP1_1926932BinaryPhysicochemical compatibilityDual phosphorylation of S927 and S932 in the TrCP1-binding motif of Nuclear factor NF-kappa-B p105 subunit (NFKB1) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
details

Probable serine/threonine-protein kinase HSL1 - HSL1 -  Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
DEG_APCC_KENBOX_2774778SpecificityDomain hidingThe KEN-box motif of APC/C-CDH1 modulator 1 (ACM1) binds to the substrate recruitment site of APC/C activator protein CDH1 (CDH1), the substrate recognition subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), and thereby blocks recruitment, and subsequent targeting for proteasomal degradation, of the Cdh1 substrate Probable serine/threonine-protein kinase HSL1 (HSL1). Degradation of Probable serine/threonine-protein kinase HSL1 (HSL1) is required for mitotic exit and maintenance of the G1 phase of the cell cycle and is allowed by Cdc20-dependent degradation of APC/C-CDH1 modulator 1 (ACM1) in anaphase.
details

Programmed cell death protein 4 - PDCD4 -  Homo sapiens
DEG_SCF_TRCP1_17076BinaryPhysicochemical compatibilityDual phosphorylation of S71 and S76 in the TrCP1-binding motif of Programmed cell death protein 4 (PDCD4) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
details

Prolactin receptor - PRLR -  Homo sapiens
DEG_SCF_TRCP1_1348353BinaryPhysicochemical compatibilityDual phosphorylation of S349 and S353 in the TrCP1-binding motif of Prolactin receptor (PRLR) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
details
DEG_SCF_TRCP1_1348353BinaryPre‑translationalAlternative Splicing removes the degron motif of Prolactin receptor (PRLR) abrogating binding to F-box/WD repeat-containing protein 11 (FBXW11). SCF-beta-TrCP2 negatively regulates the long isoform of PRLR (Isoform 1 of Prolactin receptor (PRLR)). Should be noted that TrCP2 has a predominately cytoplasmic localisation compared to TrCP1 that is located in the nucleus. The mechanism for the down-regulation of the intermediate (Isoform Intermediate of Prolactin receptor (PRLR)) and short (Isoform Short form 1a of Prolactin receptor (PRLR) and Isoform Short form 1b of Prolactin receptor (PRLR)) that lack the TrCP degron is still not known. However it should be noted that the short and intermediate are either partially deficient or entirely deficient in mediating the signal transduction pathways induced by PRL (see Kine et al. (1999) (here) and Ross et al. (1997) (here)). This though is likely due to the missing STAT5-SH2-binding motif.
details

Protein Vpu - vpu -  Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)
DEG_SCF_TRCP1_15156BinaryPhysicochemical compatibilityDual phosphorylation of S52 and S56 in the TrCP1-binding motif of Protein Vpu (vpu) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
details

Protein aurora borealis - BORA -  Homo sapiens
DEG_SCF_TRCP1_1496501BinaryPhysicochemical compatibilityDual phosphorylation of S497 and T501 in the TrCP1-binding motif of Protein aurora borealis (BORA) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
details

RE1-silencing transcription factor - REST -  Homo sapiens
DEG_SCF_TRCP1_210081013BinaryPre‑translationalAlternative splicing removes the beta-TrCP-binding degron of RE1-silencing transcription factor (REST), abrogating binding to F-box/WD repeat-containing protein 1A (BTRC), and therefore altering the half-life of the variant. Up-regulation of the protein isoform without the degron has been linked to cancer.
details

Securin - PTTG1 -  Homo sapiens
DEG_APCC_DBOX_16068SpecificityDomain hidingBinding of the second KEN-box motif of Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B), a subunit of the Spindle Assembly Checkpoint (SAC), to the substrate recruitment site of Cell division cycle protein 20 homolog (CDC20), the substrate recognition subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), blocks binding of the Cdc20 substrate Securin (PTTG1). As a result, Securin (PTTG1) is not targeted for proteasomal degradation until metaphase, when the SAC is inhibited. Destruction of Securin (PTTG1) is required for progression to the anaphase of the cell cycle.
details

Serine/threonine-protein kinase Nek2 - NEK2 -  Homo sapiens
DEG_APCC_DBOX_3423445BinaryPre‑translationalAlternative splicing removes the extended D-box degron motif of Serine/threonine-protein kinase Nek2 (NEK2), abrogating binding to Cell division cycle protein 20 homolog (CDC20). NEK2-A is targeted by APC/C-Cdc20 in early mitosis whereas Isoform Nek2B of Serine/threonine-protein kinase Nek2 (NEK2) persists into late mitosis. Degradation of Isoform Nek2A of Serine/threonine-protein kinase Nek2 (NEK2) may be necessary to allow re-establishment of the intercentriolar linkage in late mitosis.
details

Sterol regulatory element-binding protein 1 - SREBF1 -  Homo sapiens
DEG_SCF_FBW7_1425430SpecificityAltered binding specificityPhosphorylation of SREBP-1 (Sterol regulatory element-binding protein 1 (SREBF1)) at S430 generates a docking site for Glycogen synthase kinase-3 beta (GSK3B). Subsequent phosphorylation of SREBP-1 (SREBF1) by GSK3B at T426 switches the specificity of SREBP-1 (SREBF1) to the F-box/WD repeat-containing protein 7 (FBXW7), which recruits SREBP-1 (SREBF1) to the SCF ubiquitin ligase complex to mark SREBP-1 (SREBF1) for degradation.
details

Transcription factor AP-1 - JUN -  Homo sapiens
DEG_SCF_FBW7_1236243SpecificityAltered binding specificityTranscription factor AP-1 (JUN) is primed by an unknown kinase for phosphorylation by Glycogen synthase kinase-3 beta (GSK3B), which targets JUN to the SCF ubiquitin ligase complex, F-box/WD repeat-containing protein 7 (FBXW7) that marks JUN for degradation. In v-Jun (Viral jun-transforming protein (JUN)) the residue corresponding to S243 is mutated to phenylalanine, which protects v-Jun (JUN) from degradation.
details

Transcription factor HES-1 - HES1 -  Homo sapiens
LIG_WRPW_1275280SpecificityCompetitionThe Transducin-like enhancer protein 1 (TLE1) can recruit a wide range of transcriptional repressors via its WD domain, to which the WRPW motif of Transcription factor HES-1 (HES1) and the EH1 motif of Homeobox protein goosecoid (GSC) can bind using overlapping sites.
details

UDP-galactose translocator - SLC35A2 -  Homo sapiens
TRG_ER_diLys_1392396BinaryPre‑translationalAlternative splicing removes the di-lysine ER-retention motif of UDP-galactose translocator (SLC35A2), abrogating binding to Coatomer subunit alpha (COPA). This motif localises Isoform UGT1 of UDP-galactose translocator (SLC35A2) exclusively in the Golgi whereas Isoform UGT2 of UDP-galactose translocator (SLC35A2) shows dual expression in both the Golgi and the ER. This motif is considered a weak retention signal.
details

Yorkie homolog - YAP1 -  Homo sapiens
DEG_SCF_TRCP1_2383387SpecificityAltered binding specificityPhosphorylation of Yorkie homolog (YAP1) at S381 by Serine/threonine-protein kinase LATS1 (LATS1) (a key regulator of the Hippo Pathway) primes the sequence for phosphorylation by Casein kinase I isoform epsilon (CSNK1E) at S384 and S387. This targets YAP1 to the SCF ubiqutin ligase complex, F-box/WD repeat-containing protein 1A (BTRC), which marks is YAP1 for subsequent degradation by the proteasomal system. N.B. Serine/threonine-protein kinase LATS2 (LATS2) can replace LATS1 and Casein kinase I isoform delta (CSNK1D) can replace CSNK1E
details

Zinc finger protein SNAI1 - SNAI1 -  Homo sapiens
DEG_SCF_TRCP1_195100SpecificityAltered binding specificityPhosphorylation of Zinc finger protein SNAI1 (SNAI1) at S100 generates a docking site for Glycogen synthase kinase-3 beta (GSK3B). Subsequent phosphorylation of S96 by GSK3B targets Zinc finger protein SNAI1 (SNAI1) to the SCF ubiquitin ligase complexes F-box/WD repeat-containing protein 1A (BTRC), which marks it for degradation.
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