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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P21192 (2 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

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Metallothionein expression activator (Saccharomyces)


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Metallothionein expression activator - ACE2 -  Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
TRG_NES122150BinaryPhysicochemical compatibilityPhosphorylation of S137 in the NES of Metallothionein expression activator (ACE2) inhibits binding to Exportin-1 (CRM1). Phosphorylation of S137, and to a lesser extent S122, by Cbk1 directly antagonizes the interaction of Ace2 with nuclear export machinery.
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TRG_NES122150BinaryPhysicochemical compatibilityPhosphorylation of S122 in the NES of Metallothionein expression activator (ACE2) inhibits binding to Exportin-1 (CRM1). Phosphorylation of S137, and to a lesser extent S122, by Cbk1 directly antagonizes the interaction of Ace2 with nuclear export machinery.
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