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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P43403 (10 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

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T-cell surface glycoprotein CD3 epsilon chainT-cell surface glycoprotein CD3 gamma chainT-cell surface glycoprotein CD3 zeta chain
Tyrosine-protein kinase ZAP-70


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

T-cell surface glycoprotein CD3 epsilon chain - CD3E -  Homo sapiens
LIG_TYR_ITAM185202SpecificityAltered binding specificityPhosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70).
details

T-cell surface glycoprotein CD3 gamma chain - CD3G -  Homo sapiens
LIG_TYR_ITAM157174Avidity‑sensingPhosphorylation of Y160 and Y171 in the ITAM motif of T-cell surface glycoprotein CD3 gamma chain (CD3G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
LIG_TYR_ITAM157174Avidity‑sensingPhosphorylation of Y160 and Y171 in the ITAM motif of T-cell surface glycoprotein CD3 gamma chain (CD3G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details

T-cell surface glycoprotein CD3 zeta chain - CD247 -  Homo sapiens
LIG_TYR_ITAM6986Avidity‑sensingPhosphorylation of Y72 and Y83 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
LIG_TYR_ITAM6986Avidity‑sensingPhosphorylation of Y72 and Y83 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
LIG_TYR_ITAM108126Avidity‑sensingPhosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
LIG_TYR_ITAM108126Avidity‑sensingPhosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
LIG_TYR_ITAM139156Avidity‑sensingPhosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details
LIG_TYR_ITAM139156Avidity‑sensingPhosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
details

Tyrosine-protein kinase ZAP-70 - ZAP70 -  Homo sapiens
LIG_SH2_IIC284300BinaryPhysicochemical compatibilityPhosphorylation of Y292 in the SH2-binding motif of Tyrosine-protein kinase ZAP-70 (ZAP70) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.
details
           
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