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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P46013 (2 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
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MKI67 FHA domain-interacting nucleolar phosphoprotein


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

MKI67 FHA domain-interacting nucleolar phosphoprotein - MKI67IP -  Homo sapiens
LIG_FHA_2238244SpecificityAltered binding specificityPhosphorylation of T238 of MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by GSK3B. Triple-phosphorylated hNIFK (MKI67IP) binds strongly to Antigen KI-67 (MKI67).
details
LIG_FHA_2238244CumulativeRheostaticPhosphorylation of T238 in MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by Glycogen synthase kinase-3 beta (GSK3B). Triple-phosphorylated hNIFK (MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)) binds strongly to Antigen KI-67 (MKI67). See also switch details
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