About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P63104 (8 hits) x
submit


x  Coloured by switch type.
  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
Ataxin-1Forkhead box protein O4Integrin beta-2
Middle T antigen (Murine)Mitogen-activated protein kinase kinase kinase 5RAF proto-oncogene serine/threonine-protein kinase
cGMP-inhibited 3',5'-cyclic phosphodiesterase A


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Ataxin-1 - ATXN1 -  Homo sapiens
LIG_14-3-3_1772777BinaryPhysicochemical compatibilityPhosphorylation of S775 by RAC-alpha serine/threonine-protein kinase (AKT1) in the 14-3-3-binding motif of Ataxin-1 (ATXN1) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.
details
LIG_14-3-3_1772777SpecificityAltered binding specificityPhosphorylation of S775 switches binding specificity of Ataxin-1 (ATXN1) from the splicing factor Splicing factor U2AF 65 kDa subunit (U2AF2) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)). While association with the spliceosome protects ATXN1 from self-association, its phosphorylation-dependent recruitment to 14-3-3 proteins (e.g. YWHAZ) might result in aggregation.
details

Forkhead box protein O4 - FOXO4 -  Homo sapiens
LIG_14-3-3_2193199BinaryPhysicochemical compatibilityPhosphorylation of S197 by in the 14-3-3-binding motif of Forkhead box protein O4 (FOXO4) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.
details

Integrin beta-2 - ITGB2 -  Homo sapiens
LIG_14-3-3_3755760SpecificityAltered binding specificityPhosphorylation of T758 in Integrin beta-2 (ITGB2) switches the specificity of ITGB2 from Filamin-A (FLNA) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)).
details

Middle T antigen - -  Murine polyomavirus (strain 3)
LIG_14-3-3_1254259BinaryPhysicochemical compatibilityPhosphorylation of S257 in the 14-3-3-binding motif of Middle T antigen induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.
details

Mitogen-activated protein kinase kinase kinase 5 - MAP3K5 -  Homo sapiens
LIG_14-3-3_1963968BinaryPhysicochemical compatibilityPhosphorylation of S966 in the 14-3-3-binding motif of Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein. This interaction inhibits the pro-apoptotic activity of Mitogen-activated protein kinase kinase kinase 5 (MAP3K5).
details

RAF proto-oncogene serine/threonine-protein kinase - RAF1 -  Homo sapiens
LIG_14-3-3_1256261BinaryPhysicochemical compatibilityPhosphorylation of S257 in the 14-3-3-binding motif of RAF proto-oncogene serine/threonine-protein kinase (RAF1) abolishes binding of the motif, phosphorylated at S259, to 14-3-3 protein zeta/delta (YWHAZ).
details

cGMP-inhibited 3',5'-cyclic phosphodiesterase A - PDE3A -  Homo sapiens
LIG_14-3-3_2424430BinaryPhysicochemical compatibilityPhosphorylation of S428 by in the 14-3-3-binding motif of cGMP-inhibited 3',5'-cyclic phosphodiesterase A (PDE3A) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.
details
           
Please send any suggestions/comments to: switches@elm.eu.org