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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:Q96CW1 (16 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

x  Index
Asialoglycoprotein receptor 1Cytotoxic T-lymphocyte protein 4Envelope glycoprotein E (Varicella-zoster)
Envelope glycoprotein gp160 (Human)Envelope glycoprotein gp63 (Human)Epidermal growth factor receptor
Glycoprotein G (Vesicular)Lysosomal acid phosphataseLysosome-associated membrane glycoprotein 1
Neural cell adhesion molecule L1Phosphatidylinositol-4-phosphate 5-kinase type-1 gammaTransferrin receptor protein 1
VPS10 domain-containing receptor SorCS1


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Asialoglycoprotein receptor 1 - ASGR1 -  Homo sapiens
TRG_ENDOCYTIC_258BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Asialoglycoprotein receptor 1 (ASGR1) via an endocytosis motif.
details

Cytotoxic T-lymphocyte protein 4 - CTLA4 -  Homo sapiens
TRG_ENDOCYTIC_2201204BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Cytotoxic T-lymphocyte protein 4 (CTLA4) via an endocytosis motif.
details

Envelope glycoprotein E - gE -  Varicella-zoster virus (strain Oka vaccine)
TRG_ENDOCYTIC_2582585BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Envelope glycoprotein E (gE) via an endocytosis motif.
details

Envelope glycoprotein gp160 - env -  Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)
TRG_ENDOCYTIC_2712715BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Envelope glycoprotein gp160 (env) via an endocytosis motif.
details

Envelope glycoprotein gp63 - env -  Human T-cell leukemia virus 2
TRG_ENDOCYTIC_2477480BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Envelope glycoprotein gp63 (env) via an endocytosis motif.
details

Epidermal growth factor receptor - EGFR -  Homo sapiens
TRG_ENDOCYTIC_29981001BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Epidermal growth factor receptor (EGFR) via an endocytosis motif.
details

Glycoprotein G - G -  Vesicular stomatitis Indiana virus (strain San Juan)
TRG_ENDOCYTIC_2501504BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Glycoprotein G (G) via an endocytosis motif.
details

Lysosomal acid phosphatase - ACP2 -  Homo sapiens
TRG_ENDOCYTIC_2413416UncategorisedUncategorisedPhosphorylation of T156 in AP-2 complex subunit mu (AP2M1) by AP2-associated protein kinase 1 (AAK1) upon clathrin recruitment strengthens the interaction between AP-2 complex subunit mu (AP2M1) and cargo proteins.
details

Lysosome-associated membrane glycoprotein 1 - LAMP1 -  Homo sapiens
TRG_ENDOCYTIC_2414417BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Lysosome-associated membrane glycoprotein 1 (LAMP1) via an endocytosis motif.
details

Neural cell adhesion molecule L1 - L1CAM -  Homo sapiens
TRG_ENDOCYTIC_211761179BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Neural cell adhesion molecule L1 (L1CAM) via an endocytosis motif.
details
TRG_ENDOCYTIC_211761179BinaryPhysicochemical compatibilityPhosphorylation of Y1176 by Proto-oncogene tyrosine-protein kinase Src (SRC) in the endocytosis motif of Neural cell adhesion molecule L1 (L1CAM) inhibits binding to AP-2 complex subunit mu (AP2M1).
details
TRG_ENDOCYTIC_211761179BinaryPre‑translationalAlternative splicing removes the endocytosis motif of Neural cell adhesion molecule L1 (L1CAM), abrogating binding to AP-2 complex subunit mu (AP2M1). This motif is required for sorting of L1CAM to the axonal growth cone of neurons and its clathrin-mediated internalisation. Non-neuronal cells, such as Schwann cells, do not require these motifs, probably because these cells are not highly polarised.
details
TRG_ENDOCYTIC_211761179BinaryPhysicochemical compatibilityPhosphorylation of Y1176 in the endocytotic motif of Neural cell adhesion molecule L1 (L1CAM) by Proto-oncogene tyrosine-protein kinase Src (SRC) abolishes binding to the AP-2 complex subunit mu (AP2M1) and thereby inhibits internalisation of Neural cell adhesion molecule L1 (L1CAM).
details

Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma - PIP5K1C -  Homo sapiens
TRG_ENDOCYTIC_2649652BinaryPhysicochemical compatibilityPhosphorylation of S645 near the AP2-binding motif of Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) by Cyclin-dependent kinase 5 (Cdk5) inhibits its interaction with AP-2 complex subunit mu (AP2M1).
details

Transferrin receptor protein 1 - TFRC -  Homo sapiens
TRG_ENDOCYTIC_22023BinaryAllosteryBinding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Transferrin receptor protein 1 (TFRC) via an endocytosis motif.
details

VPS10 domain-containing receptor SorCS1 - SORCS1 -  Homo sapiens
TRG_ENDOCYTIC_211321135BinaryPre‑translationalAlternative splicing removes the endocytosis motif of Isoform 2 of VPS10 domain-containing receptor SorCS1 (SORCS1), abrogating binding to AP-2 complex subunit mu (AP2M1). The sequence is conserved in both human and mouse. Different splice variants have different endocytosis motifs.
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