switches.ELM

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Group by :Switch type Motif class Protein Enzyme Pathway Group Index Colouring Info Filtered: ELM:LIG_IQ_2 (2 hits) x

x Coloured by switch type.

Domain hiding	Altered binding specificity	Motif hiding	Composite binding site formation
Uncategorised	Rheostatic	Allostery	Avidity-sensing
Physicochemical compatibility	Pre-translational	Competition

x Index

Type: Binary Subtype: Pre‑translational

Protein

Motif

Start

End

Switch description

Information

*Type:* Binary *Subtype:* Pre‑translational
Pre-translational mechanisms such as alternative splicing, alternative promoter-usage and/or RNA editing result in inclusion or removal of exons that contain an entire or partial motif.
AT2B1_HUMAN	LIG_IQ_2	1114	1128	Alternative splicing partially removes the IQ motif of Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1), partially inhibiting binding to Calmodulin (CALM1).	details
AT2B1_HUMAN	LIG_IQ_2	1114	1128	Alternative splicing partially removes the IQ motif of Isoform CI of Plasma membrane calcium-transporting ATPase 1 (ATP2B1), partially inhibiting binding to Calmodulin (CALM1).	details

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